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ProteomicsIdentifying fecal host biomarkers for the presence and severity of Clostridioides difficile infection using top-down proteomics
Clostridioides difficile is a major cause of healthcare-associated diarrhea in adult patients. Laboratory diagnosis of C. difficile infection (CDI) is challenging as there is no single test combining high sensitivity and specificity, rapid turnaround time and cost efficiency. They also offer no or l...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020117 | Pride
Matrix metalloproteinase-7 Mass spectrometry Human Immunoglobulin kappa constant Biomarker discovery Free immunoglobulin light chain Stool Clostridium difficile Mouse model Proteomics Alpha-2-macroglobulin Feces Alpha-1-antitrypsin Clostridioides difficile 
ProteomicsMHC I-restricted immunopeptidomics analysis of human monocyte-derived macrophages exposed to biological nanoparticles bearing influenza hemagglutinin
In this study, primary human monocyte-derived macrophages were exposed to plant-derived virus-like particles (VLPs) bearing influenza A hemagglutinin (HA) or soluble influenza HA, as control. Immunopurified MHC class I-associated peptides were analysed by nano-flow high pressure liquid chromatograph...
ORGANISM(S): Homo sapiens (Human) 
2022-02-24 | PXD010741 | Pride
Proteomics Human antigenic peptides Dopant-assisted electrospray ionisation (da-esi) Immunopeptidomics High-resolution mass spectrometry Class i major histocompatibility complex (mhc) Virus-like particle (vlp) Monocyte-derived macrophage (mdm) 
ProteomicsTestis proteome of Trypanosoma cruzi infected mice
Male CD-1 mice (N=8) were intraperitoneally infected by culture-derived Trypanosoma cruzi trypomastigotes of the Brazil strain. One group (N=4) was treated with an antitrypanosomal drug (nifurtimox) on day 74 post-infection (chronic phase) for 20 days. A group of uninfected mice (N=3) was also inclu...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD017802 | Pride
Testis Proteomics Chagas disease Mouse Trypanosoma cruzi Lc-ms/ms 
ProteomicsHIV/HCV co-infection proteomics
Hepatic complications of HCV infection, including fibrosis and cirrhosis are accelerated in HIV-infected individuals. Although liver biopsy remains the gold standard for staging HCV-associated liver disease, this test can result in serious complications and is subject to sampling error. These challe...
ORGANISM(S): Homo sapiens (Human) 
2018-04-09 | PXD009007 | Pride
Seldi Proteomics Hcv Co-infection Liver Fibrosis Hiv Maldi Biomarker discovery Human 
ProteomicsPlant-derived virus-like particle vaccines drive cross-presentation of influenza A hemagglutinin peptides by human monocyte-derived macrophages
A growing body of evidence supports the importance of T cell responses to protect against severe influenza, promote viral clearance and ensure long-term immunity. Plant-derived virus-like particle (VLP) vaccines bearing influenza hemagglutinin (HA) have been shown to elicit strong humoral and CD4+ T...
ORGANISM(S): Homo sapiens (Human) 
2019-05-28 | PXD010519 | Pride
Influenza Cell-mediated immunity Cross-presentation Major histocompatibility complex class i Human monocyte-derived macrophage High-resolution mass spectrometry Plant-derived vaccine Virus-like particle 
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