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ProteomicsProteomics of Alzheimer's Disease mouse models
Alzheimer’s disease (AD) is a neurodegenerative disease displaying plaques formed by the neurotoxic amyloid β-peptide (Aβ) and intracellular neurofibrillary tangles consisting of protein tau. However, how these pathologies relates to the massive neuronal death that occurs in AD brains remain elusive...
ORGANISM(S): Mus musculus (Mouse) 
2015-07-29 | PXD000968 | Pride
Mosue models Brain Lc-ms Alzheimer disease 
TranscriptomicsRNA-seq of human uveal melanoma cell lines 92-1, MP41 and UM22 treated with entinostat, JQ1 or DMSO
As part of the preclinical research for a recently published trial of combination therapy with the HDAC inhibitor entinostat and the PD1 inhibitor pembrolizumab, an experiment was performed to determined the influence of entinostat and the BET inhibitor JQ1 on the transcriptome of three uveal melano...
ORGANISM(S): Homo sapiens 
2021-09-09 | E-MTAB-11058 | biostudies-arrayexpress
TranscriptomicsExpression profiling of GIST: CD133 is associated with KIT exon 11 deletion, gastric location and poor prognosis
Background & Aims: In gastrointestinal stromal tumors (GIST) KIT exon 11 deletions are associated with poor prognosis. The aim of this study was to determine the gene expression profile of GIST carrying KIT exon 11 deletions and to identify genes associated with poor prognosis. Methods: Expression p...
ORGANISM(S): Homo sapiens 
2010-06-30 | E-GEOD-14755 | biostudies-arrayexpress
UnknownBiomarkers for a less invasive strategy to predict children with eosinophilic esophagitis.
Not available
S-EPMC11657037 | biostudies-literature
TranscriptomicsConcomitant deletions of tumor suppressor genes MEN1 and AIP are essential for the pathogenesis of the brown fat tumor hibernoma
Hibernomas are benign tumors with morphological features resembling brown fat. They consistently display cytogenetic rearrangements, typically translocations, involving chromosome band 11q13. Here we demonstrate that these aberrations are associated with concomitant deletions of AIP and MEN1, tumor ...
ORGANISM(S): Homo sapiens 
2010-11-24 | E-GEOD-19040 | biostudies-arrayexpress
UnknownStellar performance: mechanisms underlying Milky Way orientation in dung beetles.
Not available
S-EPMC5312028 | biostudies-literature
ProteomicsMicrodissected pyramidal cell proteomics of Alzheimer brain reveals alterations in Creatine Kinase B, 14-3-3-g and Heat Shock Cognate 71
Novel insights on proteins involved in Alzheimer disease (AD) are needed. Since multiple cell types and matrix components are altered in AD, bulk analysis of brain tissue may be difficult to interpret. In the current study, we isolated pyramidal cells from the CA1 region of the hippocampus from five...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD028282 | Pride
Quantitative ms Alzheimer disease Q exactive Homo sapiens O18 labelling 
UnknownMany obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers.
Not available
S-EPMC4599317 | biostudies-literature
ProteomicsMnx1 Induces Leukemia Transformation Through Altering Histone Methylation in a Model of Pediatric t(7;12) Acute Myeloid Leukemia
Acute myeloid leukemia (AML) in children with cytogenetic aberrations like translocation t(7;12)(q36;p13) is associated with inferior outcome. The translocation can lead to a fusion transcript MNX1::ETV6 but also to activation of MNX1 transcription. We generated an AML mouse model by transplantatio...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-30 | PXD034416 | Pride
Aml Mnx1::etv6 Homeodomain T(7 12) Pediatric aml Mnx1 Methyl-transferases 
UnknownLigand with Two Modes of Interaction with the Dopamine D<sub>2</sub> Receptor-An Induced-Fit Mechanism of Insurmountable Antagonism.
Not available
S-EPMC7553383 | biostudies-literature
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