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ProteomicsHistone post-translational modification analysis of Aspergillus strains
Chemical modifications of DNA and histone proteins impact the organization of chromatin within the nucleus. Changes in these modifications, catalyzed by different chromatin-modifying enzymes, influence chromatin organization, which in turn is thought to impact the spatial and temporal regulation of ...
ORGANISM(S): Aspergillus niger Neosartorya fumigata (Aspergillus fumigatus) Emericella nidulans (Aspergillus nidulans) 
2022-06-30 | PXD033478 | Pride
Aspergillus Histone post-translational modifications 
ProteomicsPathology tissue-quantitative mass spectrometry analysis to profile histone post-translational modification patterns in patient samples
Histone post-translational modifications (hPTMs) generate a complex combinatorial code that has been implicated with various pathologies, including cancer. Dissecting such a code in physiological and diseased states may be exploited for epigenetic biomarker discovery, but hPTM analysis in clinical s...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2015-10-14 | PXD002669 | Pride
Biomarker  epigenetics  ffpe  super-silac  cancer 
ProteomicsHistone PTM profiling during the cell cycle
To investigate how histone post-translational modifications (PTMs) change during the cell cycle, we profiled histone H3 and histone H4 in breast cancer and normal breast cell lines arrested in G1/S or G2/M phases.
ORGANISM(S): Homo sapiens (Human) 
2019-09-09 | PXD013288 | Pride
Histone post-translational modifications Cell cycle Lc/ms Cell proliferation 
ProteomicsAlternative digestion approaches improve histone modification mapping by mass spectrometry in clinical samples
Profiling histone post-translational modifications (PTMs) in clinical samples holds great potential for the identification of epigenetic biomarkers and the discovery of novel epigenetic targets. We have recently developed a battery of mass spectrometry (MS)-based approaches to analyze histone PTMs i...
ORGANISM(S): Homo sapiens (Human) 
2010-10-08 | PXD009946 | Pride
Histone post-translational modifications Proteomics Epigenetics 
ProteomicsImproved Mass Spectrometry-based methods to study histone propionylation
Histone post-translational modifications (PTMs) have crucial roles in a multitude of cellular processes, their aberrant levels have been linked with numerous diseases, including cancer. Although histone PTM investigations have focused so far on methylations and acetylations, alternative long-chain a...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-07-11 | PXD050362 | Pride
Histone post-translational modifications Propionylation Acylation 
ProteomicsPAT-H-MS coupled with laser microdissection to study histone post-translational modifications in selected cell populations from pathology samples
Aberrations in histone post-translational modifications (hPTMs) have been linked with various pathologies, including cancer, and could represent not only useful biomarkers, but also suggest possible targetable epigenetic mechanisms. We have recently developed an approach, termed pathology tissue ana...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-07-17 | PXD006027 | Pride
Laser microdissection Epigenetic marker Histone post-translational modifications Proteomics Mass spectrometry Pat-h-ms Formalin-fixed paraffin embedded 
ProteomicsSerum proteomics profiling identifies a signature for lung cancer early diagnosis
Lung cancer is the most common cause of death from cancer worldwide, largely due to frequent late diagnosis. Thus, there is the urgent need to develop new approaches to improve theearly detection of lung cancer, which would greatly affect patient survival. The quantitative protein expression profil...
ORGANISM(S): Homo sapiens (Human) 
2023-02-13 | PXD034221 | Pride
Early diagnosis Serum Microvesicles Lung cancer Biomarker 
ProteomicsMetabolic and age-associated epigenetic barriers during direct reprogramming of mouse fibroblasts into induced cardiomyocytes
Heart disease is the leading cause of mortality in developed countries. Although conventional treatments exist, novel regenerative procedures are warranted for improving patients well fare. The use of direct cardiac conversion (DCC) of fibroblasts by the expression of the cardiogenic factors Mef2c,...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-15 | PXD046542 | Pride
Histone post-translational modifications 
ProteomicsIntestinal Differentiation Involves Cleavage of Histone H3 NTerminal Tails by Multiple Proteases
The proteolytic cleavage of histone tails, also termed histone clipping, has been described as a mechanism for permanent removal of post-translational modifications (PTMs) from histone proteins. Such activity has been ascribed to ensure regulatory function in key cellular processes such as different...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-11 | PXD022171 | Pride
Histone post-translational modifications Clipping 
ProteomicsHistone post-translational modification analysis from low-abundance clinical samples
We streamlined the protein extraction procedure from low-amount clinical samples and tested and implemented different in-gel digestion strategies, obtaining a protocol that allows the analysis of the most common histone PTMs from laser microdissected tissue areas containing as low as 1000 cells. We ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-09-09 | PXD024799 | Pride
Laser microdissection Breast cancer Histone post-translational modification 
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