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ProteomicsAn Nlrp5-null mutation leads to attenuated de novo methylation in oocytes, accompanied by significant reduction in DNMT3L
Nlrp5 encodes a core component of the subcortical maternal complex (SCMC) a cytoplasmic protein structure unique to the mammalian oocyte and cleavage-stage embryo. NLRP5 mutations have been identified in patients presenting with early embryo arrest, recurrent molar pregnancies and imprinting disorde...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-22 | PXD056859 | Pride
Nlrp5 Subcortical maternal complex Oocyte Dna methylation 
ProteomicsDnmt1 has de novo activity targeted to transposable elements
DNA methylation plays a critical role in development, particularly in repressing retrotransposons. The mammalian methylation landscape is dependent on the combined activities of the canonical maintenance enzyme Dnmt1 and the de novo Dnmts, 3a and 3b. Here we demonstrate that Dnmt1 displays de nov...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-29 | PXD025736 | Pride
Dnmt1 Uhrf1 Retrotransposon Dna methylation 
ProteomicsFASN-dependent de novo lipogenesis is required for brain development
Fate and behaviour of neural progenitor cells is tightly regulated during mammalian brain development. Metabolic pathways, such as glycolysis and oxidative phosphorylation, that are required for supplying energy and providing molecular building blocks to generate cells, govern progenitor function. H...
ORGANISM(S): Homo sapiens (Human) 
2022-01-14 | PXD026110 | Pride
Fasn Human Mouse Lipogenesis Brain development Brain organoids 
ProteomicsDe Novo Design of Tyrosine and Serine Kinase Driven Protein Switches
: Kinases play central roles in signaling cascades, relaying information from the outside to the inside of mammalian cells1. De novo designed protein switches capable of interfacing with tyrosine kinase signaling pathways would open new avenues for controlling cellular behavior, but to date no su...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD027295 | Pride
Kinase Designed proteins Switch 
GenomicsRemodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription
Recent studies suggest a hierarchical model in which lineage-determining factors act in a collaborative manner to select and prime cell-specific enhancers, thereby enabling signal-dependent transcription factors to bind and function in a cell type-specific manner. Consistent with this model, TLR4 si...
ORGANISM(S): Mus musculus 
2013-08-09 | E-GEOD-48759 | biostudies-arrayexpress
TranscriptomicsA genotype-first approach for the molecular and clinical characterization of uncommon de novo microdeletion of 20q13.33
Molecular cytogenetic techniques such as microarray analysis have allowed for a “genotype-first” approach to the characterization of chromosome abnormalities: in the absence of clinical features suggestive of a specific syndrome, patients with similar copy number imbalances can be examined for commo...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-21536 | biostudies-arrayexpress
UnknownDe Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria.
Not available
S-EPMC6631481 | biostudies-literature
UnknownInherited and De Novo Genetic Risk for Autism Impacts Shared Networks.
Not available
S-EPMC7102900 | biostudies-literature
GenomicsDe novo assembly of 150 Danish genomes reveals rich structural complexity
Most known genetic variation in human genomes has been called from comparison of short reads to the reference genome, an approach biased against finding complex variation. We sequenced 150 individuals from 50 parent-offspring trios with multiple insert-size libraries to very high coverage. We show t...
EGAS00001002108 | EGA
GenomicsDe novo DNA methylation by DNA Methyltransferase 3a controls early effector CD8+ T cell fate decisions following activation
DNMT3a is a de novo DNA methyltransferase expressed robustly after T cell activation that regulates plasticity of CD4+ T cell cytokine expression. Here we show that DNMT3a is critical for directing early CD8+ T cell effector and memory fate decisions. While effector function of DNMT3a knockout T cel...
ORGANISM(S): Mus musculus 
2016-08-20 | E-GEOD-85823 | biostudies-arrayexpress
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