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TranscriptomicsNkx6.1 regulates islet beta-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors
Loss of functional beta-cell mass is a hallmark of Type 1 and Type 2 diabetes, and methods for restoring these cells are needed. We have previously reported that overexpression of the homeodomain transcription factor Nkx6.1 in rat pancreatic islets induces beta-cell proliferation and enhances glucos...
ORGANISM(S): Rattus norvegicus 
2014-02-18 | E-GEOD-55077 | biostudies-arrayexpress
ProteomicsMitotic bookmarking redundancy by nuclear receptors mediates robust post-mitotic reactivation of the pluripotency network.
Mitotic bookmarking transcription factors (TFs) are thought to mediate rapid and accurate post-mitotic gene reactivation. However, the loss of individual bookmarking TFs often leads to the deregulation of only a small proportion of their mitotic targets, raising doubts on the significance and import...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-20 | PXD038950 | Pride
Nuclear receptors Pluripotency Esrrb Nr5a2 Es cells Mitotic bookmarking 
ModelsKolodkin2013 - Nuclear receptor-mediated cortisol signalling network
Kolodkin2013 - Nuclear receptor-mediated cortisol signalling network This model is described in the article: Optimization of stress response through the nuclear receptor-mediated cortisol signalling network. Kolodkin A, Sahin N, Phillips A, Hood SR, Bruggeman FJ, Westerhoff ...
2024-09-02 | BIOMD0000000576 | BioModels
UnknownNuclear receptors in renal health and disease.
Not available
S-EPMC8819107 | biostudies-literature
TranscriptomicsNuclear receptors Nur77 and Nurr1 modulate mesenchymal stromal cell migration
Expression analysis of migrating and non-migrating mesenchymal stromal cells (MSC) in fetal bone marrow Keywords: fetal bone marrow, mesenchymal stromal cells, migration, gene expression, genomics Three biological replates for both migrating and non-migrating mesenchymal stromal cells (MSC) in feta...
ORGANISM(S): Homo sapiens 
2011-10-23 | E-GEOD-24892 | biostudies-arrayexpress
TranscriptomicsNr4a1 and Nr4a3 upregulate cell cycle genes upregulated in the Nkx6.1 beta-cell proliferation pathway
Loss of functional beta-cell mass is a hallmark of Type 1 and Type 2 diabetes, and methods for restoring these cells are needed. Nkx6.1 induces beta-cell proliferation, but the pathway by which Nkx6.1 activates beta-cell expansion has not been defined. Here we demonstrate that Nkx6.1 induces express...
ORGANISM(S): Rattus norvegicus 
2014-02-18 | E-GEOD-55078 | biostudies-arrayexpress
GenomicsControl of cranial ectomesenchyme fate by Nr2f nuclear receptors
Control of cranial ectomesenchyme fate by Nr2f nuclear receptors
PRJNA852585 | ENA
ProteomicsPROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors
MD-224 is a PROTAC that induces degradation of the human protein MDM2. However, we have found that it also induces degradation of a subset of nuclear receptors. DIA was performed to assess the overall specificity of MD-224 in 293T cells and the colorectal cancer cell line SNU-C4.
ORGANISM(S): Homo sapiens (Human) 
2025-09-18 | PXD066110 | Pride
Dia proteomics Pxr Protac Mdm2 Nuclear receptor Md-224 
TranscriptomicsIntegrative genomics of gene and metabolic regulation by estrogen receptors α and β and coregulators [expression]
The closely related transcription factors (TFs), estrogen receptors ERα and ERβ, regulate divergent gene expression programs and proliferative outcomes in breast cancer. Utilizing MCF-7 breast cancer cells with ERα, ERβ, or both receptors as a model system to define the basis of differing response s...
ORGANISM(S): Homo sapiens 
2013-07-05 | E-GEOD-42347 | biostudies-arrayexpress
TranscriptomicsOrphan Nuclear Receptors expression and function in breast cancer cells: NR2F6 exerts a proliferative action
Orphan-Nuclear-Receptors (ONRs) are a group of ligand dependent transcriptional factors belonging to the family of Steroid-Nuclear-Receptors, which includes estrogen, progesterone and retinoic acid receptors. The ONR denomination refers to the fact that the endogenous ligands of these 15 nuclear re...
ORGANISM(S): Homo sapiens 
2025-04-15 | E-MTAB-14498 | biostudies-arrayexpress
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