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TranscriptomicsTranscription profiling of response of Rattus norvegicus frontal cortex to chronic olanzapine treatment
Male Sprague-Dawley albino rats (Charles River) initially weighting approximately 200 grams were randomly assigned to one of the following: 1) olanzapine (2 mg/kg/day, I.P.) (N=20) or 2) Saline (N=20) and administered olanzapine or saline for 21 days. Frontal cortex (N=4/group) was dissected and ho...
ORGANISM(S): Rattus norvegicus 
2007-11-03 | E-GEOD-2547 | biostudies-arrayexpress
TranscriptomicsEffects of an antipsychotic (Olanzapine) involves alterations in gene specific DNA methylation
Antipsychotic drugs are commonly used to treat psychosis, mood disorders, and anxiety. While there is indirect evidence that some component of the antipsychotic effect of these drugs may involve modulation of dopamine transmission, their mechanism of action is poorly understood. We hypothesized that...
ORGANISM(S): Rattus norvegicus 
2013-11-22 | E-GEOD-52615 | biostudies-arrayexpress
TranscriptomicsOlanzapine vs. Saline rat pfc
Male Sprague-Dawley albino rats (Charles River) initially weighting approximately 200 grams were randomly assigned to one of the following: 1) olanzapine (2 mg/kg/day, I.P.) (N=20) or 2) Saline (N=20) and administered olanzapine or saline for 21 days. Frontal cortex (N=4/group) was dissected and hom...
ORGANISM(S): Rattus norvegicus 
2007-04-10 | GSE2547 | GEO
GenomicsImpact of Chronic Olanzapine Administration on Gene Expression in the Mouse Lateral Septum
Impact of Chronic Olanzapine Administration on Gene Expression in the Mouse Lateral Septum
PRJNA1119214 | ENA
TranscriptomicsTranscription profiling of mouse frontal cortex after treatment with zntipsychotic drugs
Antipsychotic drugs are classified as typical and atypical based on extrapyramidal effects. However, since the frontal cortex is one of the most important regions for antipsychotic actions, this study attempted to classify antipsychotic drugs based on gene expression in the frontal cortex. Chlorprom...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-1501 | biostudies-arrayexpress
Methylation profilingEffects of an antipsychotic (Olanzapine) involves alterations in gene specific DNA methylation
Antipsychotic drugs are commonly used to treat psychosis, mood disorders, and anxiety. While there is indirect evidence that some component of the antipsychotic effect of these drugs may involve modulation of dopamine transmission, their mechanism of action is poorly understood. We hypothesized that...
ORGANISM(S): Rattus norvegicus 
2013-11-22 | GSE52615 | GEO
MetabolomicsGut Microbiota–Derived Ergothioneine Alleviates Antipsychotic-Induced Synaptic and Cognitive Impairments

Background: Chronic use of antipsychotic drugs is associated with neuronal damage and cognitive impairment, potentially mediated by alterations in gut microbiota metabolites, although the specific metabolite involved remains unknown.

Objective: To identify the key metabolite responsible for...

2026-04-08 | MTBLS12751 | MetaboLights
ProteomicsProteomic landscape of atypical antipsychotics clinical response in blood plasma from schizophrenia patients
Antipsychotics are the main line of treatment for schizophrenia, despite being effective only in about 50% of patients. Additionally, serious side effects may cause medication drop-out, aggravated by a lack of understanding about how these drugs act at molecular level. As proteomics is a suitable...
ORGANISM(S): Homo sapiens (Human) 
2020-06-01 | PXD015049 | Pride
Proteomics Blood plasma Mass spectrometry Olanzapine Risperidone Schizophrenia Antipsychotics 
ProteomicsA snapshot of blood plasma proteomics in clinical response to atypical antipsychotics in schizophrenia – An exploratory study
Antipsychotics are usually the first option to treat schizophrenia; however, for a considerable fraction of patients, it lacks efficacy. Furthermore, there are no known biomarkers to indicate a treatment’s efficacy in a patient. Schizophrenia causes a large socioeconomic burden on countries along wi...
ORGANISM(S): Homo sapiens (Human) 
2020-06-01 | PXD015213 | Pride
Proteomics Blood plasma Mass spectrometry Schizophrenia Antipsychotics Risperidone Olanzapine. 
TranscriptomicsImpact of Chronic Olanzapine Administration on Gene Expression in the Mouse Lateral Septum
To explore the effects of long-term olanzapine treatment on gene expression in the lateral septum of female mice, we conducted a study using female C57BL/6 mice fed with olanzapine-supplemented chow for 12 weeks. The treated mice exhibited significant weight gain and lipid alterations compared to th...
ORGANISM(S): Mus musculus 
2024-07-03 | GSE268867 | GEO
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