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ProteomicsEvaluation of Olink Reveal Proximity Extension Assay for High-Throughput Proteomics: A Case Study Using NIST SRM 1950 and Spike-In Protein Standards
Plasma proteomics has regained attention in recent years through advancements in mass spectrometry instrumentation and sample preparation, as well as new high-throughput affinity-based technologies. Here, we evaluate the analytical performance of the new Olink Reveal platform, a proximity extension ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-03 | PAD000009 | Pride
Affinity proteomics Plasma Olink reveal 
ProteomicsMulti-platforms approach for plasma: complementarity of Olink PEA technology to DIA-based mass spectrometry-based protein profiling
Plasma proteome is the ultimate target for the biomarker discovery. It stores an endless amount of information on the pathophysiological status of a living organism, which however is still difficult to comprehensively access. The high structural complexity of the plasma proteome can be addressed by ...
ORGANISM(S): Homo sapiens (Human) 
2022-03-10 | PXD020261 | Pride
Olink technology Dia-ms Kora: cooperative health research in the region of augsburg 
ProteomicsIn-depth plasma proteomics of patients with suspected lung cancer (lung adenocarcinoma and non-cancer controls) with Olink Explore 3072
Here, we present an in-depth proteomic profiling of pre-diagnostic plasma samples from 88 individuals with suspected lung cancer, including 44 patients diagnosed with stage III-IV lung adenocarcinoma (LUAD) and 44 non-cancer controls. Proteomic analysis was performed using Olink Explore 3072, which ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PAD000006 | Pride
Lung non-small cell carcinoma Lung adenocarcinoma Affinity proteomics Blood plasma Plasma proteomics Proximity extension assay Olink explore Biomarker discovery Lung cancer 
ProteomicsTargeted Plasma Proteomics Reveals a Central Role of Upregulated TNFRSF Proteins in HIV-associated Stroke: A Cross-sectional Discovery and Longitudinal Validation Study
This study investigated circulating proteomic signatures associated with stroke in people with HIV (PWH) using a nested case–control design. Plasma samples were collected from 135 HIV-positive individuals with stroke (HIV+/Stroke+), 135 HIV-positive stroke-free controls (HIV+/Stroke−), and 135 HIV-n...
ORGANISM(S): Homo sapiens (Human) 
2026-06-06 | PAD000032 | Pride
Stroke People with hiv Olink 
ProteomicsMajor depressive disorder shares systemic immune signatures and potential therapeutic targets with inflammatory skin diseases
This dataset contains normalized protein expression (NPX) values from Olink proteomic profiling of serum from patients with major depressive disorder, atopic dermatitis, psoriasis, and healthy controls, using the proximity extension assay technology across four panels: Target 96 Inflammation, Cardio...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PAD000024 | Pride
Skin Depression Inflammation Immune 
UnknownOlink Profiling of Intestinal Tissue Identifies Novel Biomarkers For Colorectal Cancer.
Not available
S-EPMC11812010 | biostudies-literature
ProteomicsHuman Plasma Discovery Proteomics
This study addresses this gap by conducting a direct comparison of eight platforms, representing both affinity-based and diverse mass spectrometry approaches, and covering over 13,000 proteins. By applying these platforms to the same cohort, we systematically assess their performance, identifying ke...
ORGANISM(S): Homo sapiens (Human) 
2025-11-06 | PAD000022 | Pride
Human Affinity-based Plasma Proteomics 
ProteomicsHuman Plasma Discovery Proteomics
This study addresses this gap by conducting a direct comparison of eight platforms, representing both affinity-based and diverse mass spectrometry approaches, and covering over 13,000 proteins. By applying these platforms to the same cohort, we systematically assess their performance, identifying ke...
ORGANISM(S): Homo sapiens (Human) 
2025-10-10 | PAD000019 | Pride
Human Affinity proteomics Plasma 
UnknownTechnical Performance Evaluation of Olink Proximity Extension Assay for Blood-Based Biomarker Discovery in Longitudinal Studies of Alzheimer's Disease.
Not available
S-EPMC9207419 | biostudies-literature
ProteomicsA lipid–immune network signature defines susceptibility to asparaginase-associated pancreatitis
Asparaginase is essential for curing acute lymphoblastic leukemia (ALL), but its use is limited by asparaginase-associated pancreatitis (AAP), a severe and unpredictable toxicity lacking validated prospective biomarkers. To define early systemic features of susceptibility, we performed longitudinal ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-31 | PAD000033 | Pride
Asparaginase associated pancreatitis Olink 
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