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ProteomicsPerformance of the Orbitrap Fusion Lumos Tribrid in single-shot analyses of human samples
One of the major additions in mass spectrometry technology has been the irruption of the Orbitrap mass analyzer, which has boosted the proteomics analyses of biological complex samples since its introduction. Here we assessed the performance of the new generation Orbitrap Fusion Lumos Tribrid mass s...
ORGANISM(S): Homo sapiens (Human) 
2017-03-09 | PXD004940 | Pride
Protein quantitation Orbitrap fusion lumos Mass spectrometry Phosphorylation Protein identification 
MetabolomicsComposition of the marine exometabolome is more stable than the functionally redundant microbial community in the oligotrophic North Atlantic

Untargeted features from the Bermuda Atlantic Time-series Study (BATS) site collected during the time period spanning 2016 to 2019. Metabolites were sampled from surface seawater to 1000 m deep and throughout the year. Dissolved organic matter extracts were analyzed in positive and negative ion m...

2024-02-28 | MTBLS5228 | MetaboLights
ProteomicsMouse liver sinusoidal endothelial cell responses to the glucocorticoid receptor agonist dexamethasone
Liver sinusoidal endothelial cells (LSECs) from C57Bl/6J male mice obtained from Charles River Laboratory (Sulzfeld, Germany) were cultured on fibronectin coated plates in 5% oxygen atmosphere in AIM-V with serum-free supplements for 1h, 10h, or 48h. Data from quantitative proteomics using a tandem ...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-25 | PXD041381 | Pride
Mus musculus Tmt sps ms3 method Orbitrap fusion lumos mass spectrometer 
MetabolomicsPhenomic and multiomic characterisation of microsatellite-stable colorectal cancer reveals novel biology and targets of vulnerability

Integrating data from approximately 2,000 tumour samples, corresponding to ~4,500 platform-specific multiomic sample profiles, and 195,246 single cells/nuclei from diverse in-house and publicly available datasets, single-to-integrated multiomic and clinical phenome data fusion analysis uncovers t...

2026-09-15 | MTBLS15127 | MetaboLights
Proteomicsproteomics analysis of senescence cells with drug
Trypsin-digested peptides were labeled using 10-plex TMT reagent (Thermo Scientific, Rockford, IL). Peptide samples (50 ug each) were labeled TMT reagents. For proteome analysis, LC-MS/MS analysis was performed using an EASY-nLC 1200 UPLC (Thermo Scientific) coupled to a Orbitrap Fusion Lumos Tribri...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-08-22 | MSV000090180 | MassIVE
ProteomicsThe ER stress sensor IRE1 interacts with STIM1 to promote store-operated calcium entry, T cell activation, and muscular differentiation
A quantitative phosphoproteomic study was performed on mouse embryonic fibroblasts (MEF) knocked-out of IRE1 protein and re rexpressin it culturen in 25mM glucose media. The chosen experimental strategy was to perform phosphopeptide enrichment associated with multiplex protein identification and qua...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-08 | PXD046579 | Pride
Ire1 Soce Er stress Stim1 
ProteomicsChemo-proteomics exploration of HDAC degradability by small molecule degraders
Cells were treated with DMSO (biological triplicate) or degrader at indicated dose and time (Meta Treatment Table) and cells were harvested by centrifugation. Lysis buffer (8 M Urea, 50 mM NaCl, 50 mM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (EPPS) pH 8.5, Protease and Phosphatase inhibito...
ORGANISM(S): Homo sapiens (Human) 
2021-07-30 | PXD023636 | Pride
Protac Imid Degrader Ubiquitin Targeted degradation E3 ligase Hdac 
MetabolomicsMetabolomic Profiling of Veillonella parvula Reveals Metabolites Associated with Colorectal Adenoma Progression
An untargeted liquid chromatography–tandem mass spectrometry (LC–MS/MS)-based metabolomics analysis was performed to characterize metabolites produced during the cultivation of Veillonella parvula. Culture supernatants collected from V. parvula cultures were compared with uninoculated culture-medium...
2026-08-21 | MTBLS15238 | MetaboLights
MetabolomicsComposition and consumption of dissolved organic carbon in seawater under sea ice

Polar regions are an under-studied environment within the global ocean, with seawater found under sea ice particularly under-sampled. This project provides concentrations of select dissolved organic carbon compounds found in under-ice seawater sampled between March and May 2023. The dissolved org...

2026-07-02 | MTBLS12381 | MetaboLights
MetabolomicsAttenuate host susceptibility to respiratory virus invasion by inhibiting interactions between host proteins SLC16A3 and AP1G1

Modulating cell endocytosis activity to reduce host susceptibility to virus represents a promising strategy for antiviral drug development. In this study, we reveal that lactate transporter SLC16A3 as a critical host factor for reducing diverse virus invasion. By performing metabolomics, proteomi...

2025-07-28 | MTBLS12788 | MetaboLights
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