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ProteomicsNovel phosphorylation substrates reveal a spatially regulated role for AAK1 in cell migration - SILAC proteome profiling to determine the impact of acute AAK1/BMP2K inhibition
NAKs (Numb-associated kinases) are a relatively unexplored kinase family that interacts with the endocytic machinery. Among NAK members, AAK1 has been linked to disorders such as neuropathic pain, schizophrenia, and Alzheimer's disease. Our goal is to better understand the cellular pathways regulate...
ORGANISM(S): Homo sapiens (Human) 
2026-03-19 | PXD055851 | Pride
Focal adhesions Lc-ms Silac Aak1 Migration Dda Bmp2k 
UnknownCryo-electron tomography of the fungal membrane-assembled retromer:Grd19 coat containing Kex2 cargo motif
Not available
EMPIAR-10631 | biostudies-other
UnknownCryo-electron tomography of the metazoan membrane-assembled retromer:SNX3 coat containing Wls cargo motif
Not available
EMPIAR-10633 | biostudies-other
TranscriptomicsLinking toxicant physiological mode of action with induced gene expression changes in Caenorhabditis elegans: atrazine
Physiologically based modelling using DEBtox (dynamic energy budget in toxicology) and transcriptional profiling were used in Caenorhabditis elegans to identify how physiological modes of action, as indicated by effects on system level resource allocation were associated with changes in gene express...
ORGANISM(S): Caenorhabditis elegans 
2010-03-23 | E-GEOD-21008 | biostudies-arrayexpress
TranscriptomicsLinking toxicant physiological mode of action with induced gene expression changes in Caenorhabditis elegans: fluoranthene
Physiologically based modelling using DEBtox (dynamic energy budget in toxicology) and transcriptional profiling were used in Caenorhabditis elegans to identify how physiological modes of action, as indicated by effects on system level resource allocation were associated with changes in gene express...
ORGANISM(S): Caenorhabditis elegans 
2010-05-05 | E-GEOD-21011 | biostudies-arrayexpress
TranscriptomicsLinking toxicant physiological mode of action with induced gene expression changes in Caenorhabditis elegans: cadmium
Physiologically based modelling using DEBtox (dynamic energy budget in toxicology) and transcriptional profiling were used in Caenorhabditis elegans to identify how physiological modes of action, as indicated by effects on system level resource allocation were associated with changes in gene express...
ORGANISM(S): Caenorhabditis elegans 
2010-05-05 | E-GEOD-21010 | biostudies-arrayexpress
UnknownABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia.
Not available
S-EPMC1852258 | biostudies-literature
ProteomicsNovel phosphorylation substrates reveal a spatially regulated role for AAK1 in cell migration - AAK1 interactome profiling
NAKs (Numb-associated kinases) are a relatively unexplored kinase family that interacts with the endocytic machinery. Among NAK members, AAK1 has been linked to disorders such as neuropathic pain, schizophrenia, and Alzheimer's disease. Our goal is to better understand the cellular pathways regulate...
ORGANISM(S): Homo sapiens (Human) 
2026-03-19 | PXD055980 | Pride
Lc-ms Dia Co-immunoprecipitation Aak1 Interactomics 
ProteomicsNovel phosphorylation substrates reveal a spatially regulated role for AAK1 in cell migration – PDLIM5 differential interactomics
PDLIM5 is a poorly explored protein, that has been shown to play a role in the maintenance of focal adhesions, likely through its interaction with actin. Our experiments demonstrate that AAK1 phosphorylates PDLIM5 on threonine 290 (T290). The aim of this experiment is to investigate the role of this...
ORGANISM(S): Homo sapiens (Human) 
2026-03-19 | PXD055912 | Pride
Lc-ms Dia Co-immunoprecipitation Pdlim5 Interactomics 
ProteomicsNovel phosphorylation substrates reveal a spatially regulated role for AAK1 in cell migration - AAK1 differential interactome profiling
NAKs (Numb-associated kinases) are a relatively unexplored kinase family that interacts with the endocytic machinery. Among NAK members, AAK1 has been linked to disorders such as neuropathic pain, schizophrenia, and Alzheimer's disease. Our goal is to better understand the cellular pathways regulate...
ORGANISM(S): Homo sapiens (Human) 
2026-03-19 | PXD055873 | Pride
Lc-ms Dia Co-immunoprecipitation Aak1 Interactomics 
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