Sort   by:  
 Page size 
MetabolomicsAge-related differences in the gut microbiota and plasma metabolome in dogs: a prospective cross-sectional study under standardized dietary conditions
Background: Aging is associated with progressive metabolic and physiological changes that influence health span in humans and may similarly impact dogs. This study aimed to characterize in the gut microbiota and their associations with host metabolism. Client-owned young adult (2-5 years, > 20 kg, n...
2026-06-26 | MTBLS14861 | MetaboLights
ProteomicsComparison of deep plasma proteome enrichment methods
Plasma is a complex biological fluid containing extracellular vesicles (EVs), residual platelets, and soluble proteins, all of which can serve as biomarkers for pathological conditions. While conventional plasma proteomics typically identifies hundreds of proteins, recent enrichment strategies have ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-17 | PXD063673 | Pride
Enrichplus Proteograph Magnet Timstof Enrichment Plasma Evs Lc-ms/ms 
ProteomicsDifferential abundance and self-organizing tree algorithm clustering nominate PDGFC and TIMP3 as candidate resection-responsive plasma extracellular vesicle proteins in head and neck cancer
Head and neck squamous cell carcinoma (HNSCC) recurs in a large proportion of patients after multimodal therapy, and no circulating marker reliably reports whether tumour-associated signals persist once the primary tumour has been removed. Because tumour-derived extracellular vesicles (EVs) accumula...
ORGANISM(S): Homo sapiens (Human) 
2026-09-22 | PXD084238 | Pride
Protein cargo Paired plasma ev samples Peripheral puncture (pp) venous blood Head and neck squamous cell carcinoma (hnscc) Tumor-draining venous (tv) blood Tumor microenvironment (tme) Extracellular vesicles (evs) Prognostic biomarker 
ProteomicsBenchmarking plasma from clinical and preclinical models
The push for new clinical biomarkers has seen rapid innovation in biofluid analysis, particularly for plasma. For mass-spectrometry (MS)-based analysis, achieving depth and quantitative accuracy whilst ensuring throughput continues to shape plasma methods development. Numerous workflows have emerged...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2026-07-27 | PXD072131 | Pride
Human Dia Serum Plasma Rat Orbitrap astral 
GenomicscfDNA dataset from extracelular vesicles and paired non-fractionated samples
Liquid biopsies contain multiple analytes that can be mined to improve the detection and management of cancer. Beyond cell-free DNA (cfDNA), mutations have been detected in DNA associated with extracellular vesicles (EV-DNA). The genome-wide composition and structure of EV-DNA remains poorly charact...
EGAS00001006848 | EGA
ProteomicsPlasma Proteomics Benchmarking and Optimisation/ Plasma proteomics across three generations of mass spectrometry instruments: lessons for optimising biomarker discovery
In biomarker discovery phases clinical proteomics provides large-scale identification and quantification of proteins in donor samples. For these studies plasma is the most frequently used biofluid, as it reflects both physiological and pathological states of the circulating proteome. However, the va...
ORGANISM(S): Homo sapiens (Human) 
2026-04-21 | PXD069060 | Pride
Plasma proteomics Astral Clinical proteomics Lcms 
ProteomicsPurification of human plasma exosomes for proteomics: optimization and application to detect changes in response to exercise
Extracellular vesicles (EVs) are released into blood from multiple organs and carry molecular cargo that facilitates inter-organ communication and an integrated response to physiological and pathological stimuli. Interrogation of the protein cargo of EVs is currently limited by the absence of optim...
ORGANISM(S): Homo sapiens (Human) 
2021-08-09 | PXD026483 | Pride
Ultracentrifugation High intensity exercise Mass spectrometry Size-exclusion chromatography Bioinformatics 
ProteomicsPlasma Proteomics Analysis of a Transglutaminase 2 inhibitor in Celiac Disease
Individuals with celiac disease (CeD) on a long-term gluten-free diet (GFD) underwent a 6-week gluten challenge combined with 100mg per day of the transglutaminase 2 enzyme -inhibitor, ZED1227 (PGCd, n = 28) or placebo (PGCp, n = 19). The samples were collected at baseline (GFD) and post-gluten chal...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD069597 | Pride
Human Lc_msms Celiac disease Plasma 
ProteomicsProteomic profiling of Extracellular Vesicles in synovial fluid and plasma from Oligoarticular Juvenile Idiopathic Arthritis patients reveals novel immunopathogenic biomarkers
New early low-invasive biomarkers are highly demanded for the management of Oligoarticular Juvenile Idiopathic Arthritis (OJIA), the most common chronic pediatric rheumatic disease in Western countries and a leading cause of disability. Despite recent significant advances in OJIA treatment, a high p...
ORGANISM(S): Homo sapiens (Human) 
2023-07-05 | PXD039166 | Pride
Proteomics Mass spectrometry Ojia Extracellular vesicles Plasma Synovial fluid 
UnknownIsolation of intact extracellular vesicles from cryopreserved samples.
Not available
S-EPMC8118530 | biostudies-literature
Sort   by:  
 Page size