Sort   by:  
 Page size 
TranscriptomicsNext Generation Sequencing Comparison of C57BL/6J and BC027072 -/- Eye Transcriptomes
We report the single base pair analysis of the ocular transcriptome from wild type and BC027072 knockout animals. Comparison was analyzed to understand gene expression changes in a mouse model for early onset retinal degeneration which phenocopies a human form of autosomal recessive retinitis pigmen...
ORGANISM(S): Mus musculus 
2015-02-03 | E-GEOD-63810 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of eye tissues from C57BL/6J background mice at 1.5 h and 9.0 h after light onset
We report RNA-Seq experiments of whole eye tissues from C57BL/6J background mice at 1.5 h and 9.0 h after light onset to better understand photoreceptor phagocytosis Examine ocular tissue from mice at different time points
ORGANISM(S): Mus musculus 
2013-08-07 | E-GEOD-48974 | biostudies-arrayexpress
TranscriptomicsRNAseq analysis of the global retinal transcriptome of rod photoreceptor-specific Dicer1 conditional knockout mice and control littermates
We report RNAseq analysis of the transcriptome of retinas from mature rod-specific Dicer1 cKO mice and control littermates lacking Cre expression in order to better understand changes in gene regulation that could lead to retinal degeneration in cKO mice. Examine retinal transcriptome of 3 biologica...
ORGANISM(S): Mus musculus 
2014-08-14 | E-GEOD-55377 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of retina and RPE/choroid tissues from wild type, Abca4 knockout and Abca4 L541P;A1038V knockin mice
We report RNA-Seq analysis of the transcriptome of retinas and RPE/choroids from Abca4 knockout, Abca4 L541P;A1038V knockin and control wild type mice in order to better understand changes in gene regulation that could lead to retinal pathology in mice with ABCA4 deficiency/defect. Retinal and RPE/c...
ORGANISM(S): Mus musculus 
2015-04-07 | E-GEOD-63772 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of mouse eye and retina tissues from wild type and Nrl transcription factor knockout mice
The initial aim of this work was to understand the pathophysiology of Enhanced S-cone Syndrome (ESCS) that leads to retinal degeneration. Although ESCS was identified in humans decades ago and since then the causative genes have been elucidated, our understanding of the accompanying retinal degenera...
ORGANISM(S): Mus musculus 
2011-06-07 | E-GEOD-29752 | biostudies-arrayexpress
Transcriptomicssmall RNAseq analysis of the global retinal transcriptome of rod photoreceptor-specific Dicer1 conditional knockout mice and control littermates
We report RNAseq analysis of the transcriptome of retinas from mature rod-specific Dicer1 cKO mice and control littermates lacking Cre expression in order to better understand changes in gene regulation that could lead to retinal degeneration in cKO mice. Examine retinal transcriptome of 3 biologica...
ORGANISM(S): Mus musculus 
2014-08-14 | E-GEOD-55376 | biostudies-arrayexpress
ProteomicsScalable purification enables high-quality virus-like particles for therapeutic translation
Emerging molecular therapies introduce enzymatic activity into cells by delivering genes, transcripts, or proteins. Owing to their robust cell-entry capacity, virus-like particles (VLPs) represent a technology of choice in genome editing, where low doses of heterologous proteins and nucleic acids ar...
ORGANISM(S): Homo sapiens (Human) 
2025-11-26 | PXD070195 | Pride
Prime editing Protein delivery Crispr/cas Nanotechnology Cas9 Chromatography Virus-like particles Base editing Vesicles Ribonuclear protein (rnp) 
ProteomicsTargeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor
G protein-coupled receptors (GPCRs) activate heterotrimeric G proteins by mediating a GDP to GTP exchange in the Gα subunit. This leads to dissociation of the heterotrimer into Gα-GTP and Gβγ dimer. The Gα-GTP and Gβγ dimer each regulate a variety of downstream pathways to control various aspects of...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-19 | PXD009503 | Pride
Lc-ms 
ProteomicsProteomic and phosphoproteomic profiling of ARPE19 cells and Abca4-/-Rdh8-/- mice exposed to stress
To obtain an unbiased, thorough understanding of the biological pathways implicated in atRAL-induced cytotoxicity and PDE inhibitor-mediated cytoprotection, we performed a mass spectrometry-based quantitative proteomic analysis of ARPE19 cells, using stable-isotope labeling of amino acids in cell cu...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-01-26 | PXD035841 | Pride
Phosphodiesterases Vision Cell culture Stress Neuroprotection Neurodegeneration Retina Lc-ms/ms 
TranscriptomicsRNAseq analysis of the global bovine retinal transcriptome
We report RNAseq analysis of the transcriptome of 3 biological replicates of bovine retina Examine retinal transcriptome of 3 biological replicates with tissue collected between 7:00 - 10:00AM
ORGANISM(S): Bos taurus 
2014-09-10 | E-GEOD-59911 | biostudies-arrayexpress
Sort   by:  
 Page size