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ProteomicsMass spectrometry analysis of proteins interacting with STAT3
Mass spectrometry analysis of proteins interacting with STAT3¬Flag was performed. STAT3-Flag was transiently expressed in HeLa cells and the interactome of STAT3-Flag was studied in lysosomal extracts. proteins co-¬immunoprecipitating with STAT3--Flag identified eight subunits of the vacuolar H+-¬ A...
ORGANISM(S): Homo sapiens (Human) 
2018-08-29 | PXD006788 | Pride
Co-immunoprecipitation Stat3 
ProteomicsLysosomal alterations in senescence
Lysosomes were isolated from proliferating and oncogene induced senescent cells and subject to LS-MS and proteomic analysis
ORGANISM(S): Homo sapiens (Human) 
2023-02-03 | PXD034358 | Pride
Lysosome Cultivated cells 
ProteomicsMouse female hippocampus proteomics of Alzheimer Tg-SwDI Model
Cerebral Amyloid Angiopathy (CAA) is a significant comorbidity in almost all cases of Alzheimer’s disease (AD) and is unaddressed by current treatment regimens. We explored the Tg-SwDI mouse model which expresses human Amyloid Precursor Protein with the familial Swedish AD mutation as well as the va...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD055083 | Pride
Alzheimer's Mouse Brain Proteomics 
ProteomicsQuantitative Proteomics Reveals Metabolic Reprogramming during ETHE1 Deficiency, Part 2
Deficiency of mitochondrial sulfur dioxygenase (ETHE1) causes the severe metabolic disorder ethylmalonic encephalopathy, which is characterized by early-onset encephalopathy and defective cytochrome C oxidase because of hydrogen sulfide accumulation. Although the severe systemic consequences of the ...
ORGANISM(S): Mus musculus (Mouse) 
2016-04-11 | PXD002742 | Pride
Metabolism Persulfide dioxygenase Acetylation Sulfide Liver Mouse Ethe1 Itraq Lc-ms/ms 
ProteomicsQuantitative Proteomics Reveals Metabolic Reprogramming during ETHE1 Deficiency, Part 1
Deficiency of mitochondrial sulfur dioxygenase (ETHE1) causes the severe metabolic disorder ethylmalonic encephalopathy, which is characterized by early-onset encephalopathy and defective cytochrome C oxidase because of hydrogen sulfide accumulation. Although the severe systemic consequences of the ...
ORGANISM(S): Mus musculus (Mouse) 
2016-04-11 | PXD002741 | Pride
Metabolism Persulfide dioxygenase Acetylation Sulfide Liver Mouse Ethe1 Itraq Lc-ms/ms 
ProteomicsLC-MS/MS proteomics of ETHE1 deficient patient fibroblasts_Study-1
The mitochondrial enzyme ETHE1 is a persulfide dioxygenase essential for cellular sulfide detoxification, and its deficiency causes the severe and complex inherited metabolic disorder ethylmalonic encephalopathy (EE). In spite of well-described clinical symptoms of the disease, detailed cellular and...
ORGANISM(S): Homo sapiens (Human) 
2018-11-07 | PXD009880 | Pride
Patient fibroblasts Ethe1 deficiency Tmt labeling Lc-ms/ms ethylmalonic acid encephalopathy 
ProteomicsLarge scale proteomics of cholesteatoma
The study describes comprehensive proteomics data of the cholesteatoma disease. Cholesteatoma is a serious and destructive growth of keratinizing squamous epithelium in the middle ear, with a poorly understood etiopathogenesis. The large scale proteomics approach used in this study highly expands ou...
ORGANISM(S): Homo sapiens (Human) 
2014-06-04 | PXD000457 | Pride
Biopsy Tympanic membrane Mucosa Middle ear Patient Cholesteatoma Epithel 
ProteomicsSynaptosome Proteomics, Fraction 4
Synaptosomes were isolated by Percoll gradient centrigation and iTRAQ based nanoLC-MS/MS proteomics. Three synapse fractions were studied from three kind of experimental rat groups namely, stressed with anhedonia, stress resilient and unstressed controls.
ORGANISM(S): Rattus norvegicus (Rat) 
2016-04-26 | PXD001777 | Pride
Depression Brain Rat Anhedonic Stress Synapses 
ProteomicsLiver proteomics of rats fed a high fat diet
S-soluble phase
ORGANISM(S): Rattus norvegicus (Rat) 
2010-12-03 | PRD000818 | Pride
ProteomicsSynaptosome Proteomics, Fraction 2
Synaptosomes were isolated by Percoll gradient centrigation and iTRAQ based nanoLC-MS/MS proteomics. Three synapse fractions were studied from three kind of experimental rat groups namely, stressed with anhedonia, stress resilient and unstressed controls.
ORGANISM(S): Rattus norvegicus (Rat) 
2016-04-26 | PXD001775 | Pride
Depression Brain Rat Anhedonic Stress Synapses 
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