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ProteomicsDysregulated lipid metabolism and hypomyelination in postnatal peroxisome-deficient Pex2 knockout Zellweger mice
In the project “Dysregulated lipid metabolism and hypomyelination in postnatal peroxisome-deficient Pex2 knockout Zellweger mice” label-free mass spectrometry proteomics was used to study the proteome in different regions of the central nervous system of wild-type and peroxisome-deficient Pex2 knock...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-28 | PXD063585 | Pride
Peroxisomes Brain Pex2 knockout mouse Cerebral cortex Cholesterol Cerebellum Cns Myelination Brainstem Zellweger syndrome Spinal cord Lc-ms/ms 
ProteomicsA synthetically methylotrophic Escherichia coli as a chassis for bioproduction
Proteome characterization of three E. coli strains: a methanol-dependent strain (MEvo1-0) and two synthetically methylotrophic strains (MEcoli_ref_1, MEcoli_ref_2)
ORGANISM(S): Escherichia coli 
2024-02-08 | PXD046243 | Pride
Synthetic biology Metabolic engineering Synthetic methylotrophy Biotechnology E. coli 
ProteomicsCharacterization of stromal cells isolated from endometriotic lesions
Endometriosis shows significant lesion heterogeneity, but pathophysiological mechanisms leading to differences in clinical presentation are poorly understood. Here we utilized primary stromal cells from different types of endometriotic lesions to better understand the molecular mechanisms that lead ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD066685 | Pride
Eutopic and ectopic endometrial cells Endometriosis Endometrioma Superficial endometriosis Endometrium Endometriotic stromal cells Homo sapiens Deep endometriosis 
ProteomicsHarnessing PROTAC technology to combat stress hormone receptor activation
We want to quantify the proteome alteration following PROTAC mediated Glucocorticoid receptor depletion in vitro.
ORGANISM(S): Homo sapiens (Human) 
2023-12-11 | PXD046949 | Pride
Gr protac A549 Lc-ms/ms 
ProteomicsEnhanced Media Optimize Bovine Myogenesis in 2D and 3D Models for Cultivated Meat Applications
Livestock farming and conventional meat production pose significant environmental, health, and animal welfare challenges. In seeking sustainable alternative solutions, cultivated meat technology typically utilizes differentiation of myogenic progenitor cells (MPCs) into muscle cells for in vitro mea...
ORGANISM(S): Bos taurus (Bovine) 
2025-07-24 | PXD051019 | Pride
Multiomics Cultivated meat Bovine 
ProteomicsAn inhibitory segment within G-patch activators tunes Prp43-ATPase activity during ribosome assembly
Mechanisms by which G-patch activators tune the processive multi-tasking ATP-dependent RNA helicase Prp43 (DHX15 in humans) to productively remodel diverse RNA:protein complexes remain elusive. Here, a comparative study between a new activator, Tma23, and a characterized activator, Pxr1, uncovered s...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-10-09 | PXD048382 | Pride
Ribosome assembly Mass spectrometry Prp43 Rna helicase 
ProteomicsIdentification of type strain-specific diagnostic peptides of the Bacillus cereus group
The Bacillus cereus group consists of eight very closely related species and comprises both harmless and human pathogenic species. Yet, methods to rapidly and accurately distinguish these species are currently lacking as we demonstrate that classical matrix-assisted laser desorption ionization-time ...
ORGANISM(S): Bacillus cereus (strain ATCC 14579 / DSM 31) Bacillus weihenstephanensis NBRC 101238 = DSM 11821 Bacillus toyonensis BCT-7112 Bacillus thuringiensis serovar berliner ATCC 10792 Bacillus pseudomycoides DSM 12442 Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98) Bacillus mycoides DSM 2048 
2018-02-07 | PXD003669 | Pride
Bacillus cereus group Type strains Diagnostic peptides Lc-ms/ms 
ProteomicsCharacterization of post-mitotic DNA synthesis and its regulation in human cells
DNA replication stress promotes cancer development and is associated with DNA synthesis beyond S-phase. Replication stress-induced DNA lesions and under-replicated DNA can persist into G2 and mitosis, where they undergo mitotic DNA synthesis (MiDAS). After cell division, inherited DNA lesions are pr...
ORGANISM(S): Homo sapiens (Human) 
2026-08-26 | PXD069839 | Pride
ProteomicsComparison of denatured and non-denatured FIH interactomes
Hypoxia occurs when tissue or cellular oxygen demand exceeds its supply and is a frequent condition in health and disease. Metazoans have developed a regulatory system that allows them to sense changes in oxygen levels in their microenvironment and adapt to them. The asparagine hydroxylase factor in...
ORGANISM(S): Homo sapiens (Human) 
2019-07-09 | PXD011252 | Pride
Covalent bond Oxygen Hypoxia Amide bond Asparagine hydroxylase Hif 
ProteomicsProtein-derived Activity Probes for Ubiquitin Pathways, ETH course 529-0046-00L
AP-MS experiment using ubiquitin-based probes as bait proteins
ORGANISM(S): Homo sapiens (Human) 
2024-09-11 | PXD053844 | Pride
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