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ProteomicsProteomic analysis of UFC1 knockdown in mouse skeletal muscle
All mouse experiments were approved by The University of Melbourne Animal Ethics Committee (AEC ID1914940) and conformed to the National Health and Medical Research Council of Australia guidelines regarding the care and use of experimental animals. C57BL/6J mice (JAX 000664) were obtained from Anima...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-08 | PXD035170 | Pride
Ufmylation Ufc1 Skeletal muscle 
ProteomicsProteomic analysis of the mouse tongue proteome in response to western diet
The tongue is a heavily innervated and vascularized striated muscle that plays an important role in vocalization and swallowing. The surface of the tongue is lined with papillae which contain gustatory cells expressing various taste receptors. There is growing evidence to suggest our perceptions of ...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD025190 | Pride
Metabolism Proteomics Obesity Tongue Taste 
ProteomicsGlycosylation analysis of TNF-alpha-induced insulin resistance
Glycoproteomics, TNF-alpha, membrane proteomics, insulin resistance, adipocyte, SILAC Insulin resistance (IR) is a complex process arising from both environmental and genetic perturbations and leads to a variety of diseases including type-2 diabetes (T2D). The expansion of adipose tissue during obes...
ORGANISM(S): Mus musculus (Mouse) 
2015-11-09 | PXD002435 | Pride
Insulin resistance Glycoproteomics Adipocyte Silac Membrane proteomics Tnf-alpha 
ProteomicsExercise-induced molecular mechanisms for glycogen supercompensation in human skeletal muscle
A single bout of exercise followed by intake of carbohydrates leads to glycogen supercompensation in the prior exercised muscle. The molecular mechanisms underlying this well-known phenomenon remain elusive. Here we report that a single bout of exercise induces marked activation of glycogen synthase...
ORGANISM(S): Homo sapiens (Human) 
2018-08-30 | PXD009196 | Pride
Human skeletal muscle exercise glycogen 
ProteomicsProteomic analysis of a targeted functional genomic screen in human skeletal muscle organoids
To begin to validate potential causal regulators of muscle function, we targeted genes containing novel skeletal muscle pQTLs and molecular/phenotypic associations, and performed a functional genomic screen in human skeletal muscle organoids (PMID: 30527761). We focused on proteins with negative ass...
ORGANISM(S): Homo sapiens (Human) 
2023-01-08 | PXD034913 | Pride
Organoids Proteomics Muscle 
ProteomicsProteomic analysis of skeletal muscle from the Hybryid Mouse Diversity Panel
To begin to understand how variations in the genome drive changes in the skeletal muscle proteome, we performed a proteomic analysis of Gastrocnemius muscle from 73 inbred mouse strains of the Hybrid Mouse Diversity Panel (HMDP) that were fed a chow diet and housed under identical environmental cond...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-08 | PXD032729 | Pride
Hybrid mouse diversity panel Skeletal muscle 
ProteomicsProteomics and phosphoproteomics of the diurnal cycle in chow and high fat high sucrose feed rats
There is growing evidence that energy metabolism and insulin action are regulated by mechanisms that follow a diurnal rhythm and it has been proposed that defects in Akt signalling are associated with the pathophysiology of metabolic disease. It is therefore important to investigate these parameters...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-05-20 | PXD010242 | Pride
Insulin signaling High fat high sucrose diet Phosphoproteomics 
ProteomicsPhosphoproteomics of rodent exercise models
Exercise stimulates systemic and tissue-specific adaptations that protect against lifestyle related diseases including obesity and type 2 diabetes. Exercise places high mechanical and energetic demands on contracting skeletal muscle, which require finely-tuned protein post-translational modification...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2019-07-22 | PXD010452 | Pride
Skeletal muscle Signal transduction Exercise Phosphoproteomics 
ProteomicsHuman adipose tissue diurnal proteomics during MASLD
Proteomics analysis of adipose tissue bioposies was performed on control and MASLD patients immediately prior to the clamp at day- (06:30 – 0:700 AM) and also night-time (06:30 – 0:700 PM) study visits.
ORGANISM(S): Homo sapiens (Human) 
2025-11-16 | PXD061275 | Pride
Adipose Human 
ProteomicsProteomic and secretomic analysis of Kusa 4B10 osteoblasts
Kusa 4B10 mesenchymal stem cells (MSCs) were differentiated into osteoblasts over 21 days and either left untreated as controls or made insulin resistant via hyperinsulinemia treatment over 2 days prior to a proteomic and secretomic analysis.
ORGANISM(S): Mus musculus (Mouse) 
2025-12-16 | PXD054479 | Pride
Insulin resistance Bone Osteoblasts Secretome 
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