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UnknownCanine and feline parvoviruses can use human or feline transferrin receptors to bind, enter, and infect cells.
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S-EPMC114880 | biostudies-literature
ProteomicsQuantification of exercise-regulated ubiquitin-signalling
The maintenance of muscle function is extremely important for whole body health and exercise is essential to this process. The ubiquitin-proteasome system (UPS) is required for muscle adaptation following exercise but little is known about acute post-translational regulation and proteome remodelling...
ORGANISM(S): Homo sapiens (Human) 
2020-03-17 | PXD016158 | Pride
Proteomics Exercise Ubiquitin 
ProteomicsMultiplexed temporal quantification of the human plasma peptidome
The plasma peptidome contains the entire complement of low molecular weight endogenous peptides derived from secretion, protease activity and post-translational modifications and is a rich source of biomarkers and novel bioactives. To examine the utility of peptidomics we have examined the effects o...
ORGANISM(S): Homo sapiens (Human) 
2017-11-21 | PXD004781 | Pride
Peptidomics Exercise Peptidome Plasma 
ProteomicsOptimising sample preparation of the plasma peptidome
We further expanded on previous optimizations to isolate the plasma peptidome and compared various methods to maximize identifications with speed and ease. Previous studies have reported loss of polypeptides binding to high abundant proteins during depletion strategies. We hypothesized that rapid c...
ORGANISM(S): Homo sapiens (Human) 
2017-10-09 | PXD007191 | Pride
Peptidomics Plasma Sample preparation 
ProteomicsProteomic analysis of L6 myoblasts treated with C-terminal transgelin peptides
To investigate bioactivity of peptides identified in human plasma, we treated L6 myoblasts in vitro with a synthetic C-terminal peptide from TAGLN spanning amino acids 179-200, or a synthetic C-terminal peptide from TAGLN2 spanning amino acids 178-199 (1 µg/mL; 7 days), and compared the treatments t...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-11-21 | PXD007176 | Pride
Peptidomics Myoblasts Proteomics 
ProteomicsProteomic analysis of ischemic and dilated cardiomyopathy pre-mortem human hearts
Our understanding of heart failure (HF) has been provided by indirect surrogates, such as post-mortem histology, cardiovascular imaging, and molecular characterisation in vivo and in vitro, rather than directly in pre-mortem human cardiac tissue. Using our heart bank of pre-mortem hearts procured ac...
ORGANISM(S): Homo sapiens (Human) 
2020-05-01 | PXD018678 | Pride
Ischemic cardiomyopathy Myocardium Dilated cardiomyopathy 
ProteomicsExercise-induced molecular mechanisms for glycogen supercompensation in human skeletal muscle
A single bout of exercise followed by intake of carbohydrates leads to glycogen supercompensation in the prior exercised muscle. The molecular mechanisms underlying this well-known phenomenon remain elusive. Here we report that a single bout of exercise induces marked activation of glycogen synthase...
ORGANISM(S): Homo sapiens (Human) 
2018-08-30 | PXD009196 | Pride
Human skeletal muscle exercise glycogen 
ProteomicsProteomic analysis of UFC1 knockdown in mouse skeletal muscle
All mouse experiments were approved by The University of Melbourne Animal Ethics Committee (AEC ID1914940) and conformed to the National Health and Medical Research Council of Australia guidelines regarding the care and use of experimental animals. C57BL/6J mice (JAX 000664) were obtained from Anima...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-08 | PXD035170 | Pride
Ufmylation Ufc1 Skeletal muscle 
ProteomicsProteomic analysis of a targeted functional genomic screen in human skeletal muscle organoids
To begin to validate potential causal regulators of muscle function, we targeted genes containing novel skeletal muscle pQTLs and molecular/phenotypic associations, and performed a functional genomic screen in human skeletal muscle organoids (PMID: 30527761). We focused on proteins with negative ass...
ORGANISM(S): Homo sapiens (Human) 
2023-01-08 | PXD034913 | Pride
Organoids Proteomics Muscle 
ProteomicsProteomic analysis of skeletal muscle from the Hybryid Mouse Diversity Panel
To begin to understand how variations in the genome drive changes in the skeletal muscle proteome, we performed a proteomic analysis of Gastrocnemius muscle from 73 inbred mouse strains of the Hybrid Mouse Diversity Panel (HMDP) that were fed a chow diet and housed under identical environmental cond...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-08 | PXD032729 | Pride
Hybrid mouse diversity panel Skeletal muscle 
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