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TranscriptomicsInhibition of PARP14 restores response to α-PD1 immune checkpoint inhibition in tumours with resistance driven by IFNγ. PARP14 study.
While immune checkpoint blockade therapy (ICBT) benefits cancer patients, many fail to maintain their response due to adaptive resistance mechanisms. IFNγ is critical for cellular immunity, but also promotes adaptive resistance to ICBT. We have established a role for PARP14 in mediating IFNγ-induced...
ORGANISM(S): Homo sapiens 
2023-08-08 | E-MTAB-12195 | biostudies-arrayexpress
ProteomicsPARP14 is a PARP with both ADP-ribosyl transferase 1 and hydrolase activities
PARP14 is a mono-ADP-ribosyl transferase involved in the control of immunity, transcription and DNA replication stress management. However, little is known about the ADP-ribosylation activity of PARP14, including its substrate specificity or how PARP14-dependent ADP-ribosylation is reversed. Here we...
ORGANISM(S): Homo sapiens (Human) 
2023-08-14 | PXD043452 | Pride
Innate immunity Dna-repair Parp13 Sars-cov Af1521-interactome Ubiquitin signaling Adpr hydrolase Parp9 Adp-ribosylation Parp14 Mono-adpr Antiviral response 
GenomicsInhibition of PARP14 restores response to α-PD1 immune checkpoint inhibition in tumours with resistance driven by IFNγ. PARP14 study.
Inhibition of PARP14 restores response to α-PD1 immune checkpoint inhibition in tumours with resistance driven by IFNγ. PARP14 study.
PRJEB56190 | ENA
ProteomicsA study into the ADP-ribosylome of IFN--stimulated THP-1 human macrophage-like cells identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-ribosylation
ADP-ribosylation is a post-translational modification that, until recently, has remained elusive to study at the cellular level. Previously dependent on radioactive tracers to identify ADP-ribosylation targets, several advances in mass spectrometric workflows now permit global identification of ADP-...
ORGANISM(S): Homo sapiens (Human) 
2020-01-27 | PXD011690 | Pride
Electron transfer higher-energy collision dissociation (ethcd) Proteomics Gas phase segmentation Higher-energy collision dissociation (hcd) Parallel reaction monitoring (prm) Orbitrap fusion lumos Post-translational modification (ptm) 
GenomicsPARP14 is a Novel Target in STAT6 Mutant Follicular Lymphoma
PARP14 is a Novel Target in STAT6 Mutant Follicular Lymphoma
PRJNA858041 | ENA
ProteomicsInterferon-Induced PARP14-Mediated ADP-Ribosylation in p62 Bodies Requires an Active Ubiquitin-Proteasome System
Biomolecular condensates are cellular compartments without enveloping membranes, enabling them to dynamically adjust their composition in response to environmental changes through post-translational modifications. A recent study has revealed that interferon-induced ADP-ribosylation (ADPr), which can...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD057944 | Pride
Dtx3l Adpr Parp P62 Biomolecular condensates 
UnknownResearch Progress on PARP14 as a Drug Target.
Not available
S-EPMC6411704 | biostudies-literature
UnknownPARP14 regulates cyclin D1 expression to promote cell-cycle progression.
Not available
S-EPMC8384455 | biostudies-literature
TranscriptomicsPARP14 is a Novel Target in STAT6 Mutant Follicular Lymphoma
The variable clinical course of follicular lymphoma (FL) is determined by the molecular heterogeneity of tumor cells and complex interactions within the tumor microenvironment (TME). IL-4 producing follicular helper T cells (TFH) are critical components of the FL TME. Binding of IL-4 to IL-4R on FL ...
ORGANISM(S): Homo sapiens 
2022-07-17 | GSE208031 | GEO
UnknownPARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation.
Not available
S-EPMC5095532 | biostudies-literature
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