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TranscriptomicsIdentification of direct transcriptional targets of V600EBRAF/MEK in melanoma
A375P melanoma cells were treated with 1uM of the MEK inhibitor PD184352 or 0.4uM of the V600EBRAF inhibitor PLX4720 for 2hr, 6hr and 24hrs. DMSO treatment for 2hr, 6hr and 24hrs serves as the negative control Triplicate experiments were performed for DMSO, PD184352 and PLX4720 treatment at 3 timepo...
ORGANISM(S): Homo sapiens 
2010-08-18 | E-GEOD-17089 | biostudies-arrayexpress
ProteomicsProduction of multifunctional hydrolysates from Lupinus mutabilis protein using a Micrococcus sp. PC7 protease
The growing demand for functional foods has driven the search for bioactive com-pounds derived from plant proteins. Lupinus mutabilis “Tarwi,” a legume native to the Peruvian Andes, stands out for its high protein content and potential as a source of bi-oactive peptides (BPs). In this study, the fun...
ORGANISM(S): Lupinus albus Phaseoleae Lupinus angustifolius Lupinus mutabilis 
2025-06-02 | PXD062562 | Pride
Lupinus mutabilis  albumin fraction  ultrafiltration  protease pc7  multifunctionality. 
TranscriptomicsDermal reprogramming through epidermal activation of beta-catenin
Hair follicle formation depends on reciprocal epidermal-dermal interactions and occurs during skin development, but not in adult life. This suggests that the properties of dermal fibroblasts change during postnatal development. To examine this, we used a PdgfraEGFP mouse line to isolate GFP-positive...
ORGANISM(S): Mus musculus 
2011-10-12 | E-GEOD-32966 | biostudies-arrayexpress
TranscriptomicsIntegrated analysis of genome-wide copy number and matched expression data reveals novel genes in esophageal adenocarcinoma
The incidence of esophageal and junctional adenocarcinoma has increased 6-fold in the west in the last 30 years and 5 year survival remains <14%. We aimed to characterize genome-wide aberrations in esophageal adenocarcinoma to further understand disease pathogenesis and ultimately identify groups wi...
ORGANISM(S): Homo sapiens 
2011-05-09 | E-GEOD-25201 | biostudies-arrayexpress
UnknownA community resource of experimental data for NMR / X-ray crystal structure pairs.
Not available
S-EPMC4815321 | biostudies-literature
UnknownQSAR and Chemical Read-Across Analysis of 370 Potential MGMT Inactivators to Identify the Structural Features Influencing Inactivation Potency.
Not available
S-EPMC10458236 | biostudies-literature
UnknownTwo-compartment tumor metabolism: autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells.
Not available
S-EPMC3404881 | biostudies-literature
UnknownSustained Increases in Cardiomyocyte Protein O-Linked β-N-Acetylglucosamine Levels Lead to Cardiac Hypertrophy and Reduced Mitochondrial Function Without Systolic Contractile Impairment.
Not available
S-EPMC10727241 | biostudies-literature
Proteomicsct of PROTAC #89, which targets an endogenously SNAP-tagged clathrin light chain, on the HAP1 cell proteome
We would like to investigate what effect degradation of the clathrin light chain has on the HAP1 proteome. We therefore tagged the clathrin light chain (CLC) in HAP1 cells endogenously with a SNAP-tag via CRISPaint. The degradation of the SNAP-tagged protein is induced by the addition of a SNAP-PROT...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049283 | Pride
Protac Clathrin Hap1 
TranscriptomicsCharacterisation of the AGO2 binding sites in HeLa cell line using eiCLIP
Here we investigate the RNA-binding protein AGO2 in HeLa by using a combination of AGO2 enhanced individual nucleotide resolution UV crosslinking and immunoprecipitation (eiCLIP). We find that 5’ capped RNAs derived from 3’UTRs likely originate from AGO2-mediated cleavage, and most often occur at lo...
ORGANISM(S): Homo sapiens 
2024-09-19 | E-MTAB-12945 | biostudies-arrayexpress
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