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ProteomicsThe effect of physiological and pathological shear stress on human endothelial cell protein abundance
Coronary artery disease remains a leading cause of mortality globally. Atherosclerosis develops at arterial sites exposed to disturbed, low, or oscillatory shear stress (OSS), while acute coronary syndromes-triggered by plaque rupture or erosion predominantly occurs in regions subjected to elevated ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD075178 | Pride
Human Endothelial cells Pathological flow lc-msms Sheer stress 
ProteomicsMitochondrial control of hypoxia-induced pathological retinal angiogenesis
Objective: Pathological retinal angiogenesis is vision threatening. In mouse oxygen-induced retinopathy (OIR) we sought to define mitochondrial respiration changes longitudinally during hyperoxia-induced vessel loss and with hypoxia-induced neovascularization (NV), and test interventions to address ...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD051410 | Pride
Lc-msms Retinal angiogenesis Neovascularization Mitochondrial respiration Hypoxia Retina Oxygen-induced retinopathy 
ProteomicsProteomic Analysis of rattus norvegicus colonic mucosa following acupuncture treatment for irritable bowel syndrome with diarrhea by label-free LC–MS/MS
To investigate the molecular pathological mechanisms of irritable bowel syndrome with diarrhea (IBS-D) and elucidate the effects of acupuncture on IBS-D colonic mucosa protein abundance in rats, a label-free high-throughput liquid chromatography-tandem mass spectrometry (LC-MS)-based proteomics anal...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-10-14 | PXD025558 | Pride
Lc-msms Colonic mucosa Rat Acupuncture 
MetabolomicsNeuroactive metabolites and bile acids are altered in extremely premature infants with brain injury

The gut microbiome has been associated with pathological neurophysiological evolvement in extremely premature infants suffering from brain injury. The exact underlying mechanism and its associated metabolic signatures in infants are not fully understood. To decipher metab...

2023-12-30 | MTBLS7560 | MetaboLights
MetabolomicsUntargeted Metabolomics of Mouse Platelet Pellets by LC-MS/MS
In this study, platelet pellets were isolated from mouse peripheral blood through gradient centrifugation to obtain high-purity platelet samples. Liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based untargeted metabolomics was performed to comprehensively profile the global metabolic chan...
2026-08-04 | MTBLS15244 | MetaboLights
ProteomicsEndothelial EphB4 maintains vascular integrity and transport function in adult heart
Dilated cardiomyopathy is a frequently occurring human disease compromising heart function and a major cause of cardiac death. The causes of cardiomyopathies are often unknown. There is increasing evidence indicating that endothelial cells lining blood vessels control the homeostasis of various orga...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-20 | PXD012575 | Pride
Metabolism Mouse Heart Lc-msms Ephb4 Endothelium Gene expression 
ProteomicsCullin-associated and neddylation-dissociated protein 1 (CAND1) alleviates NAFLD by reducing ubiquitinated degradation of ACAA2
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder with high morbidity and mortality. The current study aims to explore the role of Cullin-associated and neddylation-dissociated protein 1 (CAND1) in the development of NAFLD and the underlying mechanisms. CAND1 is reduced in t...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD043719 | Pride
Lc-msms L02 cell 
MetabolomicsRole and Mechanism of SERPINA1/PLG/TGFB1-Induced Adipose Fibroblast Activation in Dorsal Cervical Adipose Accumulation
This untargeted metabolomics study investigates metabolic differences in human adipose tissue between Group A (n=7) and Group B (n=7). Samples were analyzed using LC-MS/MS in both positive and negative ion modes on a Thermo Q-Exactive HF-X mass spectrometer. A total of 2,305 metabolites were detecte...
2026-05-08 | MTBLS14456 | MetaboLights
ProteomicsBenchmarking and integrating human B-cell receptor genomic and antibody proteomic profiling
Antibodies are immune glycoproteins that represent a crucial part of the adaptive immune system as they mediate broad protection against viruses, bacteria, and cancer. Moreover, antibodies may serve as a unique source of information on past and current physiological and pathological events in the hu...
ORGANISM(S): Homo sapiens (Human) 
2024-06-04 | PXD046237 | Pride
Human Lc-msms Plasma Antibody 
ProteomicsMapping high resolution, multidimensional phase diagrams of physiological protein condensates
Biomolecular condensates are membraneless compartments, crucial for organising and regulating diverse cellular processes. Current approaches to study condensate biology either use simplified recombinant protein systems with limited physiological relevance, or complex live-cell models with restricted...
ORGANISM(S): Homo sapiens (Human) 
2026-08-14 | PXD079312 | Pride
Lc-msms Biiomolecular condensates Als 
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