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ProteomicsLFQ proteomics analysis of M. smegmatis treated with BacPROTACs.
To monitor selective degradation of ClpC1 and ClpC2 using BacPROTAC compounds in M. smegmatis we performed a LFQ proteomics analysis treating the cells at bactericidal compound concentration. We detected degradation of both proteins and additional dysregulation of the mycobacterial PQC system.
ORGANISM(S): Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 
2023-06-07 | PXD037235 | Pride
Antibiotics Tpd Bacprotac Protac Protein degradation 
TranscriptomicsPenicillium marneffei: Gene expression profiling of hyphal and yeast cells and during conidiation
Penicillium marneffei (Talaromyces marneffei) is an opportunistic human pathogen that can grow in a multicellular hyphal form at 25M-BM-0C or a unicellular fission yeast form at 37M-BM-0C, and can switch between these two forms in response to temperature. The yeast form is found in infected individu...
ORGANISM(S): Talaromyces marneffei 
2013-11-21 | E-GEOD-51109 | biostudies-arrayexpress
ProteomicsLFQ proteomics analysis of the M. smegmatis ClpC2 interactome.
To assess the ClpC2 interactome, a IP-MS analysis was performed using ectopically expressed tagged ClpC2 in a ClpC2 deficient cell line. To evaluate potential binding sites on ClpC2, CymA treatment was applied to compete with potential interactors for a shared ClpC2 binding site.
ORGANISM(S): Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 
2023-06-07 | PXD037231 | Pride
Antibiotics Tpd Protein degradation 
ProteomicsLFQ proteomics analysis of M. smegmatis treated with CymA and ecumicin (Part 1).
To assess the impact of the bactericidal compounds CymA and ecumicin on the mycobacterial proteome and to monitor proteome remodeling by the AAA+ ClpC1 protease machinery, we performed a LFQ proteomics analysis treating the cells at sub-bactericidal compound concentration. We identified new players ...
ORGANISM(S): Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 
2023-06-07 | PXD037232 | Pride
Tuberculosis Tpd Protein degradation 
ProteomicsLFQ proteomics analysis of M. smegmatis treated with CymA and ecumicin (Part 2).
To assess the impact of the bactericidal compounds CymA and ecumicin on the mycobacterial proteome and to monitor proteome remodeling by the AAA+ ClpC1 protease machinery, we performed a LFQ proteomics analysis treating the cells at bactericidal compound concentration. We identified new players of t...
ORGANISM(S): Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 
2023-06-07 | PXD037234 | Pride
Antibiotics Tuberculosis Tpd Protein degradation 
ProteomicsConcentration and composition of the protein corona as a function of incubation time and serum concentration
We describe the concentration and composition of the protein corona as a function of incubation time (30 min and 1 day) and the concentration of fetal bovine serum (FBS) used to form the corona (5%, 10%, and 100%) on 200 nm carboxylate-modified magnetic NPs, using semi-automated processes.
ORGANISM(S): Bos taurus (Bovine) 
2023-03-21 | PXD035811 | Pride
Bovine Serum Magnetic nanoparticles Protein corona 
MetabolomicsPhotosynthetic Carbon Partitioning and Metabolic Regulation in Response to Very-Low and High CO2 in Microchloropsis gaditana NIES 2587
Photosynthetic organisms fix inorganic carbon through carbon capture machinery (CCM) that regulates the assimilation and accumulation of carbon around ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco). However, few constraints that govern the central carbon metabolism are regulated by the ca...
2022-01-14 | MTBLS1778 | MetaboLights
Proteomics5224 Payne May 2020 Data Characterize proteins binding to nanoparticle surfaces
Characterize proteins binding to nanoparticle surfaces.
ORGANISM(S): Bos taurus (Bovine) 
2020-06-10 | PXD019118 | Pride
Nano particle 
UnknownGrinding as a slaughter method for farmed black soldier fly (Hermetia illucens) larvae: Empirical recommendations to achieve instantaneous killing.
Not available
S-EPMC10951668 | biostudies-literature
UnknownMachine-learned molecular mechanics force fields from large-scale quantum chemical data.
Not available
S-EPMC11322960 | biostudies-literature
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