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ProteomicsATAD5-BAZ1B interaction modulates PCNA ubiquitination during DNA repair
Mono-ubiquitinated PCNA (mono-Ub-PCNA) is generated when replication forks stall and facilitates the DNA lesion bypass process. After resolving a replication stall, Ub-PCNA needs to be de-ubiquitinated to resume high-fidelity DNA synthesis. ATAD5 cooperates with UAF1-USP1 to de-ubiquitinate mono-Ub-...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD050108 | Pride
Baz1b De-ubiquitination Dna repair Usp1 Smarca5 Atad5 Baz1b Uaf1 Pcna 
TranscriptomicsInvolvement of a chromatin remodeling complex in damage tolerance during DNA replication
ATP-dependent chromatin remodeling complexes have been shown to participate in DNA replication in addition to transcription and DNA repair. However, the mechanisms of their involvement in DNA replication remain unclear. Here, we reveal a specific function of the yeast INO80 chromatin remodeling comp...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-20 | E-GEOD-18570 | biostudies-arrayexpress
UnknownATAD5-BAZ1B interaction modulates PCNA ubiquitination during DNA repair.
Not available
S-EPMC11615311 | biostudies-literature
UnknownA role for PCNA ubiquitination in immunoglobulin hypermutation.
Not available
S-EPMC1618868 | biostudies-literature
UnknownFANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination.
Not available
S-EPMC10842461 | biostudies-literature
UnknownFission yeast Rad8/HLTF facilitates Rad52-dependent chromosomal rearrangements through PCNA lysine 107 ubiquitination.
Not available
S-EPMC8297803 | biostudies-literature
UnknownPCNA mono-ubiquitination and activation of translesion DNA polymerases by DNA polymerase {alpha}.
Not available
S-EPMC3892766 | biostudies-literature
ProteomicsBRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis.
Deficiencies in the BRCA1 tumor suppressor gene are the main cause of hereditary breast and ovarian cancer. BRCA1 is involved in the Homologous Recombination DNA repair pathway, and, together with BARD1, forms a heterodimer with ubiquitin E3 activity. The relevance of the BRCA1/BARD1 ubiquitin E3 ac...
ORGANISM(S): Homo sapiens (Human) 
2024-05-07 | PXD050319 | Pride
Ssdna gaps Ubiquitination Brca1 Bard1 Pcna 
UnknownUnligated Okazaki Fragments Induce PCNA Ubiquitination and a Requirement for Rad59-Dependent Replication Fork Progression.
Not available
S-EPMC3688925 | biostudies-literature
UnknownA series of xanthenes inhibiting Rad6 function and Rad6-Rad18 interaction in the PCNA ubiquitination cascade.
Not available
S-EPMC8958325 | biostudies-literature
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