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ProteomicsPhosphodiesterase 2A2 (PDE2A2) interactome
Here we provide a label-free interactome of PDE2A2 tagged with a Strep-tag II epitope at the carboxyl terminal in HT-4 mouse neuroblastoma cells.
ORGANISM(S): Mus musculus (Mouse) 
2020-10-12 | PXD020486 | Pride
Pde2a2 Mitophagy Neuroblastoma cells Mitochondria Interactome 
UnknownPhosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy.
Not available
S-EPMC7578833 | biostudies-literature
ProteomicsIntegrated proteomics unveils regulation of cardiac myocytes hypertrophic growth by a nuclear cAMP nanodomain under the control of PDE3A
Signalling by cAMP is organized in multiple distinct subcellular nanodomains regulated by cAMP-hydrolysing phosphodiesterase (PDEs). Cardiac b-adrenergic signalling has served as the prototypical system to elucidate cAMP compartmentalization. Here we employed an integrated interaction and phosphopr...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-03-10 | PXD033773 | Pride
Hypertrophy Sympathetic Phosphodiesterases Adrenegic Camp 
UnknownAbnormal Cyclic Nucleotide Signaling at the Outer Mitochondrial Membrane In Sympathetic Neurons During the Early Stages of Hypertension.
Not available
S-EPMC9172895 | biostudies-literature
ProteomicsMutagenesis of Key Phosphodiesterases in Toxoplasma gondii Demonstrates the Plasticity and Therapeutic Potential of Cyclic Nucleotide Signaling
Cyclic nucleotide signaling is pivotal to the asexual growth of T. gondii; however, little do we know about its counter-regulation in this parasite. We identified 18 phosphodiesterase (PDE1-18) enzymes, most of which form apicomplexan-specific clades and lack typical regulatory motifs found in mamma...
ORGANISM(S): Cellular Organisms 
2023-02-22 | PXD032173 | JPOST Repository
TranscriptomicsS. cerevisiae mutant with a constitutively activated Ras/cAMP pathway
Comparison of the transcriptomes of Saccharomyces cerevisiae wild type FY23 and a PDE2 deletion mutant DJ28. Keywords = PDE2 Keywords = Ras/cAMP pathway
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-05 | E-GEOD-600 | biostudies-arrayexpress
TranscriptomicsCharacterization of differential gene expression in adrenocortical tumors harbouring β-catenin (CTNNB1) mutations.
Mutations of β-catenin gene (CTNNB1) are frequent in adrenocortical adenomas (AA) and carcinomas (ACC). However, the target genes of CTNNB1 have not yet been identified in adrenocortical tumors. Our objective was to identify genes de-regulated in adrenocortical tumors harbouring CTNNB1 genetic alter...
ORGANISM(S): Homo sapiens 
2011-04-09 | E-GEOD-28476 | biostudies-arrayexpress
TranscriptomicscAMP/PKA signaling balances respiratory activity with mitochondria dependent apoptosis via transcriptional regulation
This data provides evidence that elevation of cAMP levels has a dramatic effect on the transcriptome of yeast cells, with particular emphasis on mitochondrial function and the promotion of ROS production S. cerevisiae cells lacking the high affinity phosphodiesterase PDE2or both PDE2 and the PKA sub...
ORGANISM(S): Saccharomyces cerevisiae 
2010-11-24 | E-GEOD-25541 | biostudies-arrayexpress
TranscriptomicsReduced protein kinase A signaling can diminish the nuclear transcriptional response to mtDNA damage in Saccharomyces cerevisiae
Damage to the mitochondrial genome (mtDNA) severely affects the cell and causes disease. Mutations to mtDNA also accumulate throughout the lifespan of many organisms and may be a proximal cause of aging. There is no effective treatment for ailments caused by mtDNA mutation. Since mitochondrial funct...
ORGANISM(S): Saccharomyces cerevisiae 
2015-08-07 | E-GEOD-71252 | biostudies-arrayexpress
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