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ProteomicsIn-depth serum proteomics of hospitalized COVID-19 patients and PCR-negative healthy controls with HiRIEF LC-MS/MS
We performed in-depth MS-based plasma-proteome profiling in 20 hospitalised patients with COVID-19 and 7 healthy controls (PCR- and sero-negative for SARS-CoV-2) by high-resolution isoelectric focusing (HiRIEF) coupled with liquid chromatography and mass-spectrometry (LC-MS/MS). The SARS‐CoV‐2 PCR‐c...
ORGANISM(S): Homo sapiens (Human) 
2023-09-01 | PXD037486 | Pride
Covid-19 Human Serum Plasma Sars-cov-2 Hirief Lc-ms/ms 
ProteomicsiEvaluation of spin columns for human plasma depletion to facilitate MS-based proteomics analysis of SARS-cov-2 positive plasman columns for human plasma depletion to facilitate MS-based proteomics analysis of SARS-cov-2 positive plasma
the benefit on the number of identified proteins is well documented and the depletion step remains widely used in in-depth proteomics. Recently, single-use depletion spin columns have been developed (i.e High Select™ Top14 Abundant Protein Depletion Mini Spin Columns, Thermo) which greatly reduces ...
ORGANISM(S): Homo sapiens (Human) Macaca mulatta (Rhesus macaque) 
2021-07-30 | PXD023148 | Pride
Proteomics Mass spectrometry Plasma Depletion Sars-cov-2 Human Spin-column 
ProteomicsMelanoma metastases: association between S100A13 expression and chemotherapy resistance
Here we have performed quantitative profiling of the proteome of lymph node metastasis from patients with melanoma with different response to chemotherapy.
ORGANISM(S): Homo sapiens (Human) 
2014-04-25 | PXD000928 | Pride
Lymph nodes Isoelectric focusing Melanoma S100a13 Metastasis 
ProteomicsHigh resolution proteome profiling of multiple neighboring regions with each tumor tissue of patients with melanoma brain metastasis using bulk tumor sequencing.
Our study provides a comprehensive multiomics overview of each patient’s tumor, revealing tumor cell types, proteomics, and transcriptomic changes related to melanoma brain metastasis (MBM). Here, we have applied the HiRIEF pre-fractionation and tandem mass tags (TMT)-16plex based peptide quantifica...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD055170 | Pride
Pd-1 Proteomics Multi-omics Immunotherapy Immune signaling Transcriptomics Targeted therapy Melanoma brain metastases 
ProteomicsHigh resolution proteome profiling of multiple neighboring regions with each tumor tissue of patients with melanoma brain metastasis using bulk tumor sequencing.
Our study provides a comprehensive multiomics overview of each patient’s tumor, revealing tumor cell types, proteomics, and transcriptomic changes related to melanoma brain metastasis (MBM). Here, we have applied the HiRIEF pre-fractionation and tandem mass tags (TMT)-16plex based peptide quantifica...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD055172 | Pride
Pd-1 Proteomics Multi-omics Immunotherapy Immune signaling Transcriptomics Targeted therapy Melanoma brain metastases 
ProteomicsHigh resolution proteome profiling of multiple neighboring regions with each tumor tissue of patients with melanoma brain metastasis using bulk tumor sequencing.
Our study provides a comprehensive multiomics overview of each patient’s tumor, revealing tumor cell types, proteomics, and transcriptomic changes related to melanoma brain metastasis (MBM). Here, we have applied the HiRIEF pre-fractionation and tandem mass tags (TMT)-16plex based peptide quantifica...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD055089 | Pride
Pd-1 Proteomics Multi-omics Immunotherapy Immune signaling Transcriptomics Targeted therapy Melanoma brain metastases 
UnknownPlasma proteome alterations by MAPK inhibitors in BRAFV600-mutated metastatic cutaneous melanoma.
Not available
S-EPMC8274243 | biostudies-literature
ProteomicsPlasma Hirief - In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta
Novel method for plasma proteomics and proteogenomics
ORGANISM(S): Homo sapiens (Human) 
2019-04-10 | PXD010899 | Pride
Plasma proteogenomics 
ProteomicsPlasma protein corona on superparamagnetic iron oxide nanoparticles (SPIONs)
We determined the composition of the plasma protein corona on silica-coated versus dextran-coated iron oxide nanoparticles using mass spectrometry-based proteomics approaches. Gene ontology (GO) enrichment analysis and Ingenuity Pathway Analysis (IPA) revealed distinct protein corona compositions fo...
ORGANISM(S): Homo sapiens (Human) 
2015-10-12 | PXD000766 | Pride
Protein corona Superparamagnetic Nanoparticles Mass spectrometry Macrophages 
ProteomicsProteomics analysis of cystic fluid from human cystic papillary thyroid carcinoma
Here we have performed quantitative and qualitative profiling of the proteome of cystic fluid from human cystic papillary thyroid carcinoma with the aim to identify specific proteins and pathways involved in cystic fluid from human cystic papillary carcinoma, as well as possible diagnostic markers.
ORGANISM(S): Homo sapiens (Human) 
2015-05-20 | PXD000996 | Pride
Cystic fluid Isoelectric focusing Biomarker discovery Proximal fluid Papillary thyroid carcinoma 
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