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ProteomicsFeasibility of phosphoproteomics to uncover oncogenic signalling in secreted extracellular vesicles using glioblastoma-EGFRVIII cells as a model
Cancer cells secrete extracellular vesicles (EVs) that contain molecular information, including proteins and RNA. Oncogenic signalling can be transferred via the cargo of EVs to recipient cells and may influence the behaviour of neighbouring cells or cells at a distance. This cargo may contain cance...
ORGANISM(S): Homo sapiens (Human) 
2023-10-17 | PXD046189 | Pride
Exosome Phospho-proteomics Glioblastoma multiforme Egfr Inka Lc-ms/ms Extracellular vesicles 
ProteomicsPhosphoproteomic Profiling of T-Cell Acute Lymphoblastic Leukemia Identifies Targetable Kinases and Combination Treatments
Protein kinase inhibitors are amongst the most successful cancer treatments, but targetable kinases activated by gene fusions are rare in T-ALL (e.g., NUP214-ABL1). Nevertheless, leukemic blasts rely on enhanced kinase signaling to sustain dysregulated proliferation. Protein kinases can be hyper-act...
ORGANISM(S): Homo sapiens (Human) 
2022-02-21 | PXD024807 | Pride
Human Single-shot T-all Ptyr Label-free Phosphoproteomics T-cell acute lymphoblastic leukemia 
ProteomicsHS_CSF_microvesicles
Proteomics of cerebrospinal fluid microvesicles
ORGANISM(S): Homo Sapiens (human) 
2014-12-31 | PAe005110 | PeptideAtlas
ProteomicsDPHL v2: An updated and comprehensive DIA pan-human assay library for quantifying more than 14,000 proteins
we generated DPHL v2 from 1608 DDA-MS data acquired using Orbitrap mass spectrometers. The data included 586 DDA-MS newly acquired from 17 tissue types, while 1022 files were derived from DPHL v1. DPHL v2 thus comprises data from 24 sample types, including several cancer types . We generated four va...
ORGANISM(S): Homo Sapiens 
2023-01-18 | PXD039313 |
UnknownPhosphoproteomic profiling of T cell acute lymphoblastic leukemia reveals targetable kinases and combination treatment strategies.
Not available
S-EPMC8881579 | biostudies-literature
UnknownA novel nonsense mutation of ERCC2 in a Vietnamese family with xeroderma pigmentosum syndrome group D.
Not available
S-EPMC7008115 | biostudies-literature
OtherProteomic analysis of cerebrospinal fluid extracellular vesicles: A comprehensive dataset.
Data from ProteomeXchange, PXD ID: PXD000608. File: QE1_120417_OPL0006_16_CSFexosomes_SP_DC_G3.mzml. Published as part of J Proteomics. 2014 Apr 24 . From the Abstract: {{i}} Extracellular vesicles (EVs) are present in human cerebrospinal fluid (CSF), yet little is known about their protein composi...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310000045 | GPMDB
Resource Reanalysis 
UnknownType VI Collagen Regulates Endochondral Ossification in the Temporomandibular Joint.
Not available
S-EPMC9059467 | biostudies-literature
ProteomicsQuantitative phosphoproteomic analysis reveals dendritic cell- specific STAT signaling after α2-3–linked sialic acid ligand binding
Dendritic cells (DCs) are key initiators of the adaptive immunity, and upon recognition of pathogens are able to skew T cell differentiation to elicit appropriate responses. DCs possess this extraordinary capacity to discern external signals using receptors that recognize pathogen-associated molecul...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024443 | Pride
Human Dendritic cells Lps Α2-3 sialic acid Single-shot Modc Jak-stat Label-free Phosphoproteomics 
ProteomicsCo-expression analysis of label-free proteomics data reveals prognostic biomarkers in pancreatic ductal adenocarcinoma
Despite extensive biological and clinical studies, including comprehensive genomics and transcriptomics analysis, pancreatic ductal adenocarcinoma (PDAC) remains a devastating disease, with poor survival and no effective therapies to date. Correlation networks are emerging as a powerful approach to ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-15 | MSV000096427 | MassIVE
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