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ProteomicsLimits for resolving isobaric tandem mass tag reporter ions using phase constrained spectrum deconvolution
A popular method for peptide quantification relies on isobaric labeling such as tandem mass tags (TMT) which enables multiplexed proteome analyses. Quantification is achieved by reporter ions generated by fragmentation in a tandem mass spectrometer. However, with higher degrees of multiplexing, the ...
ORGANISM(S): Homo sapiens (Human) 
2018-10-05 | PXD011009 | Pride
Q exactive hf-x Phase constrained spectrum deconvolution Tmt Resolution Quantitative proteomics 
ProteomicsEnhancing tandem MS sensitivity and peptide identification via ion pre-accumulation in an Orbitrap mass spectrometer
High-throughput mass spectrometry-based proteomics is gaining increasing interest, but mass spectrometers need to adapt to enable faster analysis times. For Orbitrap mass spectrometers, faster scan rates are constrained by limitations on ion accumulation time, duty cycle, and transient length. Here,...
ORGANISM(S): Homo sapiens (Human) 
2026-02-16 | PXD061135 | Pride
Lc-ms Dia Pre-accumulation Proteomics Dda 
ProteomicsFull Mass Range PhiSDM Orbitrap Mass Spectrometry for DIA Proteome Analysis
Optimizing data-independent acquisition (DIA) methods for proteomics applications often requires balancing spectral resolution and acquisition speed. Here we describe the full mass range application of Phase-constrained Spectrum Deconvolution Method (PhiSDM) for OrbitrapTM mass spectrometry in real ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-09 | PXD044292 | Pride
Proteomics Orbitrap High-throughput Data-independent acquisition Phisdm 
MetabolomicsAROMA-GC: Green Automated Plasma Metabolome Profiling

Metabolomics enables the comprehensive profiling of low–molecular weight metabolites that reflect the interplay between environmental exposures and endogenous biological processes. As the downstream output of genomic, transcriptomic, proteomic, and epigenomic networks, the metabolome provides the...

2026-08-24 | MTBLS13319 | MetaboLights
ProteomicsMice primary T cell phosphotyrosine proteomics enabled by BOOST
Signal propagation mediating numerous cellular processed in T cells is orchestrated by tyrosine phosphorylation with a high degree of regulation1, 2. Because aberrant tyrosine phosphorylation can result in many diseases3, a method to systematically quantify this dynamic process can be helpful in und...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-04 | PXD025853 | Pride
T cell Boost Phosphotyrosine proteomics Tmt Mice 
UnknownEnhancing Tandem MS Sensitivity and Peptide Identification via Ion Preaccumulation in an Orbitrap Mass Spectrometer.
Not available
S-EPMC12322952 | biostudies-literature
UnknownFull Mass Range ΦSDM Orbitrap Mass Spectrometry for DIA Proteome Analysis.
Not available
S-EPMC10851225 | biostudies-literature
ProteomicsUrinary proteome profiling in Parkinson’s disease
The prevalence of Parkinson's disease (PD) is increasing but the development of novel treatment strategies and therapeutics altering the course of the disease would benefit from specific, sensitive and non-invasive biomarkers to detect PD early. Here, we describe a scalable and sensitive proteomics ...
ORGANISM(S): Homo sapiens (Human) 
2020-11-24 | PXD020722 | Pride
Urine Proteomics Dia Mass spectrometry Neurodegeneration Parkinson’s disease Body fluid Biomarker Lc-ms/ms 
ProteomicsProteome Profiling of Cerebrospinal Fluid reveals novel biomarker candidates for Parkinson’s disease
Parkinson's disease (PD) is a growing burden worldwide, and despite ongoing efforts to find reliable biomarkers for early and differential diagnosis, prognosis and disease monitoring, there is no biofluid biomarker used in clinical routine to date. Cerebrospinal fluid (CSF) is collected often and sh...
ORGANISM(S): Homo sapiens (Human) 
2022-06-01 | PXD026491 | Pride
Proteomics Csf Parkinson's disease Biomarker 
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