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ProteomicsThe protein phosphatase 2A holoenzyme is a key regulator of starch metabolism and bradyzoite differentiation in Toxoplasma gondii
Phenotypic switching from tachyzoite to bradyzoite and vice versa is the fundamental mechanism underpinning the pathogenicity and adaptability of the protozoan parasite Toxoplasma gondii. Accumulation of cytoplasmic starch granules is a hallmark of the quiescent bradyzoite stage. The regulatory fact...
ORGANISM(S): Toxoplasma gondii 
2022-11-05 | PXD033120 | Pride
Pp2a holoenzyme Toxoplasma gondii Differentiation Dephosphorylation. Starch metabolism 
ProteomicsPhactr1/PP1 phosphatase substrates in mouse primary neurons
Neurons express Phactr1 at high level (Allen et al., 2004), and Phactr1 mutations are associated with morphological and functional developmental defects in cortical neurons (Hamada et al., 2018). To identify targets of the Phactr1/PP1 phosphatase holoenzyme, we cultured hippocampal and cortical neur...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-28 | PXD019882 | Pride
Neurons Phosphatase Mouse Phactr1 
ProteomicsPhactr1/PP1 phosphatase substrates in mouse NIH3T3 fibroblasts
It was previously shown that expression of an activated Phactr1 mutant (Phactr1XXX) that constitutively forms the Phactr1/PP1 phosphatase holoenzyme, induces F-actin rearrangements in NIH3T3 fibroblasts. Expression of the Phactr1 PP1-binding domain (C-terminal) alone is also sufficient to induce suc...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-28 | PXD019977 | Pride
Phosphatase Mouse Phactr1 Fibroblasts 
UnknownPPM1G forms a PPP-type phosphatase holoenzyme with B56δ that maintains adherens junction integrity.
Not available
S-EPMC6776900 | biostudies-literature
ProteomicsMapping the substrate landscape of protein phosphatase 2A catalytic subunit PPP2CA
Protein phosphatase 2A (PP2A) is an essential Ser/Thr phosphatase that regulates a plethora of cellular processes. PP2A operates as a holoenzyme complex, comprising one each of the scaffolding (A), regulatory (B) and catalytic (C) subunits. PPP2CA is the principal catalytic subunit of the PP2A holoe...
ORGANISM(S): Homo sapiens (Human) 
2024-03-18 | PXD045779 | Pride
Targeted protein degradation Ppp2ca Phosphatase Dtag Phospho-proteomics Phosphorylation Pp2a Kinase Protac Substrate landscape 
UnknownGeneration of active protein phosphatase 2A is coupled to holoenzyme assembly.
Not available
S-EPMC1885835 | biostudies-literature
ProteomicsSDS22 coordinates the assembly of holoenzymes from nascent protein phosphatase-1
SDS22 forms an inactive complex with nascent protein phosphatase-1 (PP1) and Inhibitor-3 (I3). SDS22:PP1:I3 is a substrate for the ATPase p97/VCP, which liberates PP1 for binding to canonical regulatory subunits. The exact role of SDS22 in PP1-holoenzyme assembly remains elusive. Here, we show that ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-03-18 | MSV000094347 | MassIVE
ProteomicsThe PP2A-2 holoenzyme orchestrates daughter cell emergence during cytokinesis in Toxoplasma gondii
Toxoplasma gondii is a significant pathogen affecting both humans and animals, with clinical symptoms primarily driven by the uncontrolled proliferation of tachyzoites. In this study, we reveal the essential role and functional plasticity of the PP2A-2 holoenzyme in orchestrating daughter cell emerg...
ORGANISM(S): Toxoplasma gondii 
2025-08-21 | PXD064226 | Pride
Toxoplasma gondii  pp2a-2 phosphatase  cytokinesis  cell division  daughter cell emergence  phosphoproteomics 
UnknownStructure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation.
Not available
S-EPMC2818795 | biostudies-literature
UnknownProtein-Protein Interactions and Quantitative Phosphoproteomic Analysis Reveal Potential Mitochondrial Substrates of Protein Phosphatase 2A-B'ζ Holoenzyme.
Not available
S-EPMC10346264 | biostudies-literature
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