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ProteomicsLoss of colonic primary cilia promotes inflammation and carcinogenesis
Primary cilia (PC) are important signaling hubs in cells and we explored their role in colorectal cancer (CRC) and colitis. In the colon we found PC to be mostly present on different subtypes of fibroblasts and exposure of mice to either chemically induced colitis-associated colon carcinogenesis (CA...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-29 | PXD033440 | Pride
Colon carcinogenesis Inflammation Primary cilia Colonic fibroblasts Colitis 
UnknownProteomic meta-analysis unveils new frontiers for biomarkers research in pancreatic carcinoma.
Not available
S-EPMC11830788 | biostudies-literature
ProteomicsProteomics approach unravels early changes in Human Fibro-blasts-Pancreatic Ductal Adenocarcinoma cells crosstalk
Pancreatic ductal adenocarcinoma (PDAC) is a leading causes of cancer mortality worldwide. Non-specific symptoms, lack of biomarkers in the early stages, and drug resistance due to the presence of a dense fibrous stroma all contribute to poor outcome of this disease. The extracellular matrix of PDAC...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD030974 | Pride
Cancer associated fibroblasts  pdac microenvironment  proteomics  ingenuity pathway analysis 
ProteomicsEpigenetic Impairment of tumor potential of AML-derived extracellular vesicles
The biological active cargo of leukemia-derived extracellular vesicles (EVs) favours a wide variety of cancer-supportive mechanisms, including aberrant proliferative signalling, immune escape and drug resistance. However, whether and in which extent anti-neoplastic drugs affect EV cargo sorting is ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD042168 | Pride
Vesicle Leukemia Tumorigenicity Epigenetic Saha 
ProteomicsMacroH2A1.1 as a crossroad between epigenetics, inflammation and metabolism of mesenchymal stromal cells in myelodysplastic syndromes
Ineffective hematopoiesis is a hallmark of myelodysplastic syndromes (MDS). Hematopoietic alterations in MDS patients strictly correlate with microenvironment dysfunctions, eventually affecting also the mesenchymal stromal cells (MSCs) compartment. Stromal cells are indeed epigenetically reprogramme...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD039866 | Pride
Myelodysplastic syndromes Proteomics Macroh2a1.1 
ProteomicsMagnetic resonance imaging and transcriptome-proteome integration analysis demonstrate improved disease-outcome in the cuprizone mouse model following AAV-mediated delivery of A Proliferation Inducing Ligand
A Proliferation Inducing Ligand (APRIL) is a member of the tumour necrosis factor (TNF) superfamily and has recently been shown to modulate pro-inflammatory astrocyte responses, as well as to ameliorate disease outcome in the experimental autoimmune encephalomyelitis mouse model for multiple scleros...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-10 | PXD056011 | Pride
Cuprizone Adeno-associated virus Neuroprotection Neuroinflammation Magnetic resonance imaging Transcriptomics Proteomics April 
UnknownProtein Kinase C Activation Drives a Differentiation Program in an Oligodendroglial Precursor Model through the Modulation of Specific Biological Networks.
Not available
S-EPMC8156399 | biostudies-literature
UnknownSerum lipidomic study reveals potential early biomarkers for predicting response to chemoradiation therapy in advanced rectal cancer: A pilot study.
Not available
S-EPMC5514249 | biostudies-literature
UnknownInvestigating Different Forms of Hydrogen Sulfide in Cerebrospinal Fluid of Various Neurological Disorders.
Not available
S-EPMC7998212 | biostudies-literature
UnknownMetabolomic Signature in Sera of Multiple Sclerosis Patients during Pregnancy.
Not available
S-EPMC6274842 | biostudies-literature
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