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ProteomicsALS Associated Mutations in Matrin 3 Alter Protein-Protein Interactions and Impede mRNA Nuclear Export
Mutations in Matrin 3 have recently been linked to ALS, though the mechanism of disease in these patients is still unknown. To define the protein interactome of wild-type and ALS-linked MATR3 mutations, we performed immunoprecipitation followed by mass spectrometry experiments in NSC-34 cells expres...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-15 | PXD007710 | Pride
Als Lc/ms-ms Trex Matrin-3 
ProteomicsMedulloblastoma Patient-Derived Xenograft Proteomics
Proteomic and phosphoproteomic characterization of 20 orthotopic patient-derived xenograft models of medulloblastoma
ORGANISM(S): Homo sapiens (Human) 
2022-09-01 | PXD035070 | Pride
Proteomics Medulloblastoma Phosphoproteomics Patient-derived xenograft (pdx) Lc-ms/ms 
ProteomicsMolecular profiling of innate immune response mechanisms in ventilator associated pneumonia (VAP)
Ventilator associated pneumonia (VAP) is the 2nd most common hospital acquired infection associated with high morbidity, mortality and increased hospitalization. Current practice of diagnosis is based on clinical symptoms and bronchoalvolar lavage (BAL) culture. The procedures of BAL collections are...
ORGANISM(S): Homo sapiens (Human) 
2020-07-27 | PXD010715 | Pride
Lc-ms/ms Bronchoalveolar lavage Ventilator associated pneumonia Endotracheal aspirates 
ProteomicsProteomic response of macrophages to human cancer Raji cells
In order to determine changes in phosphorylation events in macrophages upon phagocytosis of cancer cells, mouse macrophages were co-cultured with human Raji cancer cells. Macrophages were collected as 0, 1, 15, 60 and 120 minutes after incubation. Phosphosite abundances were compared between timepoi...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD053542 | Pride
Macrophages Phosphorylation Lc-ms/ms 
ProteomicsDefining the Caprin-1 interactome in unstressed and stressed conditions
IP-MS was utilized to identify Caprin-1 protein-protein interactions in stress and unstressed conditions.
ORGANISM(S): Homo sapiens (Human) 
2021-05-07 | PXD023271 | Pride
Human Stress granules Caprin-1 Ip-ms Protein-protein interactions 
ProteomicsProteomic analysis identifies plasma correlates of remote ischemic conditioning in the context of experimental traumatic brain injury
Remote ischemic conditioning (RIC) treatment has been shown to modify levels of traumatic brain injury (TBI) pathology related proteins, however, the mechanism is not widely understood. This study utilized LC-MS/MS to identify protein biomarkers of RIC treatment after TBI in mouse models.
ORGANISM(S): Mus musculus (Mouse) 
2021-06-03 | PXD020420 | Pride
Traumatic brain injury Proteomics Remote ischemic conditioning Biomarkers 
ProteomicsLC-MS/MS proteomics analysis of Panc-1 EVs isolated using SEC
LC-MS/MS proteomics analysis of Panc-1 EVs isolated using SEC
ORGANISM(S): Homo sapiens (Human) 
2019-10-24 | PXD012660 | Pride
Extracellular vesicles Lc-ms/ms 
ProteomicsProteomic characterization of NHL cells in presence of CDK9 inhibitor
non-Hodgkins lymphoma cells were treated with a CDK9 inhibitor to determine which proteins and phosphorylation events are affected by CDK9 in lymphoma.
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD035858 | Pride
Lymphoma Phosphoproteomics Mass spectrometry Cdk9 
ProteomicsProteomics Characterization of Longitudinal CSF from ALS Fast and Slow Progressors
Each CSF sample was concentrated and added to a multiple affinity removal spin cartridge .The eluates were subjected to a buffer exchange and proteins were reduced using DTT and alkylated using iodoacetamide. Digestions were performed using trypsin. CSF from patients with amyotrophic lateral scleros...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD035026 | Pride
Amyotrophic lateral sclerosis Mass spectrometry Csf 
ProteomicsIntegrative synaptosome multi-omics reveals disrupted synapse organization and localized cryptic transcripts in C9ORF72-Frontotemporal Dementia
Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are linked neurodegenerative diseases characterized by both synaptic dysfunction and TDP-43 pathology. A hexanucleotide repeat expansion (HRE) in the C9ORF72 (C9) gene represents the most common genetic cause of FTD and ALS, yet t...
ORGANISM(S): Homo sapiens (Human) 
2026-09-28 | PXD083082 | Pride
Frontotemporal dementia Synaptosome Amyotrophic lateral sclerosis 
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