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GenomicsChromatinized PKC-q directly regulates inducible genes in epithelial to mesenchymal transition and breast cancer stem cells
Epithelial to mesenchymal transition (EMT) is activated during cancer invasion and metastasis, enriches for cancer stem cells (CSCs), and contributes to therapeutic resistance and disease recurrence. Signal transduction kinases play a pivotal role as chromatin-anchored proteins in eukaryotes. Here w...
ORGANISM(S): Homo sapiens 
2014-06-22 | E-GEOD-53320 | biostudies-arrayexpress
ProteomicsLarge-scale in vitro kinase assay with FLNc d23-24 and PKC alpha
Large-scale in vitro kinase assay with human and murine FLNc and its site mutants and PKC alpha.
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2017-01-02 | PXD003185 | Pride
Lc-ms In vitro kinase assay Flnc Pkc alpha 
TranscriptomicsPKC Activation Induces Inflammatory Response and Cell Death in Human Bronchial Epithelial Cells
A variety of airborne pathogens can induce inflammatory responses in airway epithelial cells, which is a crucial component of host defence. However, excessive inflammatory responses and chronic inflammation also contribute to different diseases in the respiratory system. We hypothesized that the ac...
ORGANISM(S): Homo sapiens 
2013-05-27 | E-GEOD-44747 | biostudies-arrayexpress
TranscriptomicsThe role of PKCtheta in Epithelial to Mesenchymal Transistion
Epithelial to mesenchymal transition (EMT) is activated during cancer invasion and metastasis, enriches for cancer stem cells (CSCs), and contributes to therapeutic resistance and disease recurrence. Signal transduction kinases play a pivotal role as chromatin-anchored proteins in eukaryotes. Here w...
ORGANISM(S): Homo sapiens 
2014-06-22 | E-GEOD-53267 | biostudies-arrayexpress
ProteomicsIdentification of PKC-alpha dependent phosphoproteins in mouse retina
Adjusting to a wide range of light intensities is an essential feature of retinal rod bipolar cell (RBC) function, and persuasive evidence suggests this modulation involves phosphorylation by protein kinase C-alpha (PKC-alpha). PKC-alpha is a serine/threonine kinase that is strongly expressed in RBC...
ORGANISM(S): Mus musculus (Mouse) 
2019-07-15 | PXD012906 | Pride
Mouse Isobaric labeling Protein kinase c-alpha Quantitative proteomics Signaling Retina 
TranscriptomicsTranscription profiling of mouse PKCa -/- mutant vs. wild type small intestine
Members of the PKC family of serine / threonine kinases play key regulatory roles in numerous cellular processes including differentiation and proliferation. Of the eleven mammalian PKC isoforms known several have been implicated in tumor development and progression. However, in most cases isotype s...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3915 | biostudies-arrayexpress
GenomicsRegulation of inducible genes in epithelial to mesenchymal transition by chromatinized PKC-theta
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-06-22 | E-GEOD-53335 | biostudies-arrayexpress
ProteomicsPKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain
Leucine-rich-repeat-kinase 1 (LRRK1) and its homologue LRRK2 are multidomain kinases possessing an atypical ROC-CORA-CORB containing GTPase domain and phosphorylate distinct Rab proteins. LRRK1 loss of function mutations cause the bone disorder osteosclerotic metaphyseal dysplasia, whereas LRRK2 mis...
ORGANISM(S): Homo sapiens (Human) 
2022-09-02 | PXD034420 | Pride
Rab7a Lrrk1 Pkc Phosphorylation 
TranscriptomicsPKC-dependent MYRF dysregulation links Aβ pathology to oligodendrocyte, myelin and cognitive alterations in Alzheimer’s disease
Alzheimer’s disease (AD) is characterized not only by neuronal loss and synaptic dysfunction but also by emerging evidence of oligodendrocyte and myelin pathology. Amyloid-β (Aβ), a hallmark of AD, disrupts oligodendrocyte homeostasis through mechanisms that remain poorly understood. Here, we invest...
ORGANISM(S): Mus musculus 
2025-12-31 | E-MTAB-16400 | biostudies-arrayexpress
GenomicsProtein kinase C alpha gene sequences of sphingid moths (Lepidoptera, Sphingidae)
PKC alpha gene sequences of sphingid moths
PRJEB30488 | ENA
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