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MetabolomicsThe Impacts of Sortase A and the 4'-Phosphopantetheinyl Transferase Homolog Sfp on Streptococcus mutans Extracellular Membrane Vesicle Biogenesis

Extracellular membrane vesicles (EMVs) are produced by many Gram-positive organisms, but information regarding vesiculogenesis is incomplete. We used single gene deletions to evaluate the impacts on Streptococcus mutans EMV biogenesis of Sortase A (SrtA), which affects S. mutans...

2021-10-06 | MTBLS1812 | MetaboLights
MetabolomicsMetabolome and proteome changes in skeletal muscle and blood of pre-weaning calves fed leucine and threonine supplemented diets

In pre-weaning calves, both leucine and threonine play important roles in growth and muscle metabolism. In this study, metabolomics, proteomics and clinical chemistry were used to assess the effects of leucine and threonine supplementation added to milk replacer on 14 newborn Holstein male calves...

2020-02-20 | MTBLS1045 | MetaboLights
ProteomicsA Peptidisc-based Survey of the Plasma Membrane Proteome of a Mammalian Cell
The low abundance and hydrophobicity of plasma membrane proteome relative to soluble proteins makes it difficult to characterize. Here, we apply the peptidisc membrane mimetic to purify the cell membrane proteome. We used HeLa cells as a reference to establish the method, and compared the plasma mem...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD039990 | Pride
Plasma membrane proteome Peptidisc 
ProteomicsPlasma membrane proteome of adhesion-competent endometrial epithelial cells and its modulation by Rab11a
Human endometrial epithelium (EE) is composed of a multitude of proteins, amongst which those localized on the plasma membrane (plasma membrane proteins-PMPs) are of critical relevance in early stages of implantation. Evidences support the key role of few PMPs in implantation. However, many remain u...
ORGANISM(S): Homo sapiens (Human) 
2019-11-08 | PXD015010 | Pride
Epithelium Plasma membrane Ishikawa Proteomics Endometrium 
ProteomicsRNAi-mediated downregulation of poplar plasma membrane intrinsic proteins (PIPs) changes plasma membrane proteome composition and affects leaf physiology
Plasma membrane intrinsic proteins (PIPs) are one subfamily of aquaporins that mediate the transmembrane transport of water. To reveal their function in poplar, we generated transgenic poplar plants in which the translation of PIP genes was downregulated by RNA interference investigated these plants...
ORGANISM(S): Populus canescens (Grey poplar) (Populus tremula x Populus alba) 
2015-08-10 | PXD002544 | Pride
Plasma membrane intrinsic protein  populus × canescens  plasma membrane proteomics  photosynthesis  stomatal movement Aquaporin  pip 
ProteomicsImproved plasma membrane proteome coverage with a label-free non-affinity-purified workflow
The proteins of the cellular plasma membrane perform important functions relating to homeostasis and intercellular communication. Due to its overall low cellular abundance, amphipathic character, and low membrane-to-cytoplasm ratio, the plasma membrane proteome has been challenging to isolate and ch...
ORGANISM(S): Homo sapiens (Human) 
2017-01-31 | PXD004801 | Pride
Label-free  proteomics  plasma membrane  go term  leukemia 
ProteomicsA conserved signaling network monitors delivery of sphingolipids to the plasma membrane in budding yeast.
48 total runs: three biological replicates, 8 runs each, each run as technical duplicates
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2017-04-13 | MSV000080919 | MassIVE
ProteomicsCell membrane proteome analysis in HEK293T cells challenged with α-Synuclein amyloids
Amyloids interact with plasma membranes. Extracellular amyloids cross the plasma membrane barrier. Internalized extracellular amyloids are reported to trigger amyloidogenesis of endogenous proteins in recipient cells. To what extent these extracellular and intracellular amyloids perturb the plasma ...
ORGANISM(S): Homo sapiens (Human) 
2024-07-09 | PXD046280 | Pride
Membrane shaving Internalization Α-synuclein Plasma membrane Amyloids 
ProteomicsRabA2b overexpression alters the Plasma-Membrane Proteome and Improves Drought Tolerance in Arabidopsis
Rab proteins are small GTPases that are important in the regulation of vesicle trafficking. RabA2b was identified through data mining to be stress responsive. Little is known about the involvement of RabA in plant responses to abiotic stresses. Promoter analysis of RabA2b showed strong activity duri...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-02-15 | PXD028140 | Pride
Arabidopsis Plasma-membrane Drought 
ProteomicsA Peptidisc-based Survey of the Plasma Membrane Proteome of a Mammalian Cell
The low abundance and hydrophobicity of plasma membrane proteome relative to soluble proteins makes it difficult to characterize. Here, we apply the peptidisc membrane mimetic to purify the cell membrane proteome. We used HeLa cells as a reference to establish the method, and compared the plasma mem...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD041913 | Pride
Hela Peptidiscs Membrane proteins Hpsc Panc-1 cells Lc-ms/ms 
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