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TranscriptomicsTowards a reference human platelet transcriptome: evaluation of inter-individual correlations and of its relationship with a platelet proteome
For the anucleate platelet it has been unclear how well platelet transcriptomes correlate among different donors or across different RNA profiling platforms, and what the transcriptomes’ relationship is with the platelet proteome. We generated RNA-seq pro-files of the long R...
ORGANISM(S): Homo sapiens 
2015-01-20 | E-GEOD-50858 | biostudies-arrayexpress
ProteomicsEarly-stage cancer biomarkers uncovered in the blood platelet proteome
Platelets play an important role in tumor growth and at the same time, platelet characteristics are affected by cancer presence. Therefore, we investigated whether the platelet proteome can be used as a source for biomarkers of early-stage cancer. Patients with early-stage lung (n=8) and head of pan...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-08-29 | MSV000082867 | MassIVE
ProteomicsHuman platelet detergent resistant membranes proteome
Here we characterized the proteins associated with detergent resistant membranes (DRMs) from resting and activated human platelets. We achieved a proteomic profile of 141 DRM proteins involved in many biological pathways including 'PAR-1-mediated thrombin signal events', 'Integrin family cell surfac...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080708 | MassIVE
ProteomicsThe platelet releasate in healthy population and pregancy
Upon activation, platelets release a multitude of soluble and vesicular signals, collectively termed the ‘platelet releasate’ (PR). This PR plays an important role in haemostasis, wound healing and the inflammatory response. We and others have used qualitative/quantitative proteomic approaches to ch...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-08-29 | MSV000082866 | MassIVE
TranscriptomicsPlatelet RNA-Seq
Platelet-rich plasma (PRP) has been obtained by centrifuging whole blood at 160 g for 15 min at room temperature. Platelets have been activated with 2 different physiologic agonists, namely collagen (60ug/mL) or Thrombin Receptor Activating Peptide (TRAP 25uM) under continuous stirring. An aliquot o...
ORGANISM(S): Homo sapiens 
2015-04-27 | E-MTAB-2355 | biostudies-arrayexpress
ProteomicsSpecific proteome changes in platelets from individuals with GATA1-, GFI1B- and RUNX1-linked bleeding disorders
Mutations in the transcription factors GATA1, GFI1B and RUNX1 (GATA Binding Factor 1, Growth Factor Independence 1B, Runt-related transcription factor 1) cause familial platelet and bleeding disorders. Mutant platelets exhibit common abnormalities including an α-granule reduction. This suggests that...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD020343 | Pride
Platelet disorders Bleeding Transcription factors Runx1 Gata1 Gfi1b 
ProteomicsPlatelet proteome dynamics in hibernating 13-lined ground squirrels
Hibernating mammals undergo a dramatic drop in temperature and blood flow during torpor and must suppress hemostasis to avoid stasis blood clotting. In addition, cold storage of most mammalian platelets induces cold storage lesions, resulting in rapid clearance following transfusion. 13-lined ground...
ORGANISM(S): Ictidomys tridecemlineatus arenicola 
2021-12-08 | PXD026903 | Pride
Platelets Platelet cold storage Psr-ohsu Platelet transfusion Hibernation Torpor Tmt labeling Quantitative proteomics 
TranscriptomicsAspirin Exposure Reveals Novel Genes Associated with Platelet Function and Cardiovascular Events (outpatient cardiology)
Background: Identifying individuals at heightened cardiovascular risk is a priority for reducing the global burden of cardiovascular disease. Aspirin is widely used to prevent cardiovascular events, though with variable results. Therefore, we hypothesized that aspirin exposure would reveal novel b...
ORGANISM(S): Homo sapiens 
2013-12-06 | E-GEOD-38511 | biostudies-arrayexpress
ProteomicsFunctional class assignment of the complete platelet proteome and transcriptome
Advances in platelet transcriptomics allow prediction of the full human platelet proteome. We integrated proteomes from six cohorts, encompassing 5.2k unique proteins (3.5k with copy numbers), with novel genome-wide platelet and megakaryocyte transcriptomes (Blueprint).
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022011 | Pride
Proteomics Human platelets Transcriptomics 
ProteomicsDeciphering changes to human platelet proteome and degradome during storage before transfusion
Proteases, and specifically metalloproteinases, have been linked to the loss of platelet function during storage before transfusion, albeit the mechanism remains unknown. We used a dedicated N-terminomics technique, multiplex iTRAQ-TAILS (Terminal Amine Isotope Labeling of Substrates), to characteri...
ORGANISM(S): Homo sapiens (Human) 
2014-10-24 | PXD000906 | Pride
Platelets Metalloproteinases Degradome Proteases Tails Human Ls-msms 
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