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MetabolomicsTwo apples a day modulate human:microbiome co-metabolic processing of polyphenols, tyrosine and tryptophan

PURPOSE: Validated biomarkers of food intake (BFIs) have recently been suggested as a useful tool to assess adherence to dietary guidelines or compliance in human dietary interventions. Although many new candidate biomarkers have emerged in the last decades for different foods fr...

2020-04-28 | MTBLS469 | MetaboLights
MetabolomicsHost: Microbiome co-metabolic processing of dietary polyphenols – An acute, single blinded, cross-over study with different doses of apple polyphenols in healthy subjects
Apples are one of the most commonly consumed fruits and their high polyphenol content is considered one of the most important determinants of their health-promoting activities. Here we studied the nutrikinetics of apple polyphenols by UHPLC-HRMS metabolite fingerprinting, comparing the bioavailabili...
2018-10-11 | MTBLS473 | MetaboLights
ModelsNookaew2008_Yeast_MetabolicNetwork_iIN800
This is a reconstruction of the metabolic network of the yeast Saccharomyces cerevisiae as described in the article: The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism. Nookaew I...
2005-01-01 | MODEL1002240000 | BioModels
ProteomicsPhosphoproteomics of TrkA and TrkB signaling in SH-SY5Y neuroblastoma cells
Human neuroblastoma cells (SH-SY5Y) were engineered to have stable expression of either TrkA (NTRK1) or TrkB (NTRK2) receptors. The cells were pretreated with 0.5 μM Trametinib, 2.5 μM Gefitinib, and combination of 0.25 μM Trametinib and 1.25 μM Gefitinib. Stimulation of TrkA and TrkB-expressing SH-...
ORGANISM(S): Homo sapiens (Human) 
2022-04-13 | PXD028943 | Pride
Phosphoproteomics Neuroblastoma. 
Proteomics(Full Proteome) Kinase Suppressor of RAS 1 (KSR1) maintains the transformed phenotype of BRAFV600E mutant human melanoma cells
KSR1 is a scaffolding protein for the RAS-RAF-MEK-ERK pathway, which is one of the most frequently altered pathways in human cancers. Previous results have shown that KSR1 has a critical role in mutant RAS mediated transformation. Here, we examined the role of KSR1 in mutant BRAF transformation. We ...
ORGANISM(S): Homo sapiens (Human) 
2023-08-15 | PXD036265 | Pride
Ksr1 Proteomics. Ras-raf-mek-erk pathway Cancer 
ProteomicsA structure-based modelling approach identifies effective drug combinations for RAS-mutant acute myeloid leukemia
Abstract Mutations activating RAS/RAF/MEK/ERK signaling are associated with poor outcome in acute myeloid leukemia (AML), but therapeutic targeting of this pathway is challenging. Here, we employ a structure-based, dynamic RAS pathway model to successfully predict RAF inhibitor (RAFi) combinations ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-24 | PXD063606 | Pride
Drug combinations Ras-mutant acute myeloid leukemia. Structure-based modelling 
ProteomicsOXPHOS TARGETING OF MYCN-AMPLIFIED NEUROBLASTOMA
High risk - neuroblastoma (HR-NB) is a pediatric solid tumor with high lethality. Half of HR-NB are driven by MYCN gene amplification (MNA). These HR-NBs require high dosage chemotherapy and often relapse. Moreover, current therapies can cause severe long-term side effects and new therapies are urge...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD069621 | Pride
Neuroblastoma Dpi Mitoq Childhood cancer Combination therapy Metabolism. Oxidative stress 
ProteomicsProteomic profile of BxPC3 cells after RAD51 inhibition by treatment with BRC4
RAD51 protein is an evolutionarily conserved recombinase that plays a central role in homologous recombination (HR) and DNA double strand break (DSB) repair. RAD51 inactivation by small molecules has been proposed as a strategy to impair the BRCA2/RAD51 binding and, ultimately, the HR pathway, with ...
ORGANISM(S): Homo sapiens (Human) 
2023-08-15 | PXD042696 | Pride
Proteomie Rad51 Bxpc3 cells Brc4. 
ProteomicsIKKα modulates colorectal cancer metastasis by counteracting tight junction stabilization and collective cell migration.
The IKK kinase was previously found to activate multiple oncogenic and therapy-resistance pathways, including ATM/DDR, BRD4, and JAK/STAT3, independently of canonical NF-B signaling. Here, we show that suppression of IKK, either genetically or pharmacologically, imposes a pro-metastatic activity on ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-01 | PXD057102 | Pride
Ikkα Cell migration. Colorectal cancer Metastasis 
ProteomicsInvestigating Synthetic Lethality and PARP Inhibitor Resistance in Pancreatic Cancer Through Enantiomer Differential Activity
The RAD51-BRCA2 interaction is central to DNA repair through homologous recombination. Emerging evidence indicates RAD51 overexpression and its correlation with chemoresistance in various cancers, suggesting RAD51-BRCA2 inhibition as a compelling avenue for intervention. We previously showed that co...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054120 | Pride
Anticancer drugs  homologous recombination  parp inhibitors  protein-protein small molecule inhibitors  parpi resistance  within-pathway synthetic lethality (wpsl) 
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