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ProteomicsDownregulation of LATS kinases alters p53 to promote cell migration
p53 is a pivotal tumor suppressor and a major barrier against cancer. We now report that silencing of the Hippo pathway tumor suppressors LATS1 and LATS2 in non-transformed mammary epithelial cells reduces p53 phosphorylation and increases its association with the p52 NF-κB subunit. Moreover, it pa...
ORGANISM(S): Homo sapiens (Human) 
2018-10-25 | PXD003120 | Pride
Cancer Cell-migration Nfkb2 Tp53 Homeostasis Cox-2 
ProteomicsInner ear proteomics/transcriptomics
The correlation between expression levels of mRNA and protein in mammals is relatively low, with a Pearson correlation coefficient of ~0.40. Post transcriptional regulation contributes to this low correlation. Across taxa, it was demonstrated that translation efficiency, i.e. the protein-to-mRNA rat...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-24 | PXD003379 | Pride
Vestibule Ear Protein Correlation Cochlea Mrna 
TranscriptomicsDownregulation of LATS kinases alters p53 to promote cell migration
p53 is a pivotal tumor suppressor and a major barrier against cancer. We now report that silencing of the Hippo pathway tumor suppressors LATS1 and LATS2 in non-transformed mammary epithelial cells reduces p53 phosphorylation and increases its association with the p52 NF-?B subunit. Moreover, it par...
ORGANISM(S): Homo sapiens 
2015-12-11 | E-GEOD-74493 | biostudies-arrayexpress
ProteomicsCryptococcal infectome uncovers new therapeutic targets
Mortality and morbidity rates of invasive fungal infections are rising as new pathogens emerge, antifungal resistance rates rise, and susceptible populations increase in numbers. Innovative strategies to identify and characterize novel druggable targets and investigate mechanisms of action driving f...
ORGANISM(S): Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) 
2026-05-20 | PXD051675 | Pride
Virulence Fungal Infectome 
UnknownA technical guide to TRITEX, a computational pipeline for chromosome-scale sequence assembly of plant genomes.
Not available
S-EPMC9719158 | biostudies-literature
UnknownNitrogen deficiency tolerance conferred by introgression of a QTL derived from wild emmer into bread wheat.
Not available
S-EPMC11255033 | biostudies-literature
ProteomicsCryptococcal infectome uncovers new therapeutic targets
Mortality and morbidity rates of invasive fungal infections are rising as new pathogens emerge, antifungal resistance rates rise, and susceptible populations increase in numbers. Innovative strategies to identify and characterize novel druggable targets and investigate mechanisms of action driving f...
ORGANISM(S): Mus musculus (Mouse) Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) 
2026-05-20 | PXD051506 | Pride
Drug discovery Virulence Quantitative proteomics Immunization Fungal pathogenesis Infection Phenome 
UnknownIdentification of a gene signature for discriminating metastatic from primary melanoma using a molecular interaction network approach.
Not available
S-EPMC5725601 | biostudies-literature
UnknownAssessing Four Quality Indicators for Multiple Sclerosis Management Through Patient-Reported Data.
Not available
S-EPMC4984792 | biostudies-literature
UnknownGenetic map-guided genome assembly reveals a virulence-governing minichromosome in the lentil anthracnose pathogen Colletotrichum lentis.
Not available
S-EPMC6668012 | biostudies-literature
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