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ProteomicsDownregulation of LATS kinases alters p53 to promote cell migration
p53 is a pivotal tumor suppressor and a major barrier against cancer. We now report that silencing of the Hippo pathway tumor suppressors LATS1 and LATS2 in non-transformed mammary epithelial cells reduces p53 phosphorylation and increases its association with the p52 NF-κB subunit. Moreover, it pa...
ORGANISM(S): Homo sapiens (Human) 
2018-10-25 | PXD003120 | Pride
Cancer Cell-migration Nfkb2 Tp53 Homeostasis Cox-2 
ProteomicsInner ear proteomics/transcriptomics
The correlation between expression levels of mRNA and protein in mammals is relatively low, with a Pearson correlation coefficient of ~0.40. Post transcriptional regulation contributes to this low correlation. Across taxa, it was demonstrated that translation efficiency, i.e. the protein-to-mRNA rat...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-24 | PXD003379 | Pride
Vestibule Ear Protein Correlation Cochlea Mrna 
TranscriptomicsDownregulation of LATS kinases alters p53 to promote cell migration
p53 is a pivotal tumor suppressor and a major barrier against cancer. We now report that silencing of the Hippo pathway tumor suppressors LATS1 and LATS2 in non-transformed mammary epithelial cells reduces p53 phosphorylation and increases its association with the p52 NF-?B subunit. Moreover, it par...
ORGANISM(S): Homo sapiens 
2015-12-11 | E-GEOD-74493 | biostudies-arrayexpress
ProteomicsBreast cancer tumors
The project analyzed 88 breast cancer clinical samples, including lymph node negative and positive primary tumors, lymph node metastases, and healthy tissue as control. All samples were combined with a super-SILAC mix that served as an internal standard for quantification.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-06-16 | MSV000079830 | MassIVE
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