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ProteomicsSIRT1 regulates DNA damage signaling through PP4 phosphatase complex
The Sirtuin family of NAD+-dependent enzymes play an important role in the maintenance of genome stability upon stress. Several mammalian Sirtuins have been linked directly or indirectly to the regulation of DNA damage during replication through Homologous recombination (HR). The role of one of them...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-06-15 | PXD036905 | Pride
Label free proteomics Pp4 phosphatase complex H2ax Sirt1 Dna damage response 
ProteomicsPervasive phenotypic effects of FBXO42 promoted by regulation of PP4 phosphatase
Abstract F-box proteins are the substrate recognition modules of the SCF (SKP1–Cullin–F-box) E3 ubiquitin ligase complex. FBXO42, an understudied member of this family, has recently emerged as a modulator of key cellular processes, including cell cycle progression, DNA damage response and glioma ste...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD069593 | Pride
Cancer Fbxo42 Scf Ppp phosphatases Ubiquitin 
ProteomicsPervasive phenotypic effects of FBXO42 promoted by regulation of PP4 phosphatase
F-box proteins are the substrate recognition modules of the SCF (SKP1–Cullin–F-box) E3 ubiquitin ligase complex. FBXO42, an understudied member of this family, has recently emerged as a modulator of key cellular processes, including cell cycle progression, DNA damage response and glioma stem cell su...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD069542 | Pride
Cancer Fbxo42 Scf Ppp phosphatases Ubiquitin 
ProteomicsPervasive phenotypic effects of FBXO42 promoted by regulation of PP4 phosphatase
F-box proteins are the substrate recognition modules of the SCF (SKP1–Cullin–F-box) E3 ubiquitin ligase complex. FBXO42, an understudied member of this family, has recently emerged as a modulator of key cellular processes, including cell cycle progression, DNA damage response and glioma stem cell su...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD069496 | Pride
Cancer Fbxo42 Scf Ppp phosphatases Ubiquitin 
UnknownSIRT1 regulates DNA damage signaling through the PP4 phosphatase complex.
Not available
S-EPMC10359614 | biostudies-literature
ProteomicsA consensus binding motif for the PP4 protein phosphatase reveals its role as a regulator of cohesin release
Regulation of protein activities through phosphorylation is a fundamental regulatory mechanism in all organisms. Phosphoprotein phosphatase 4 (PP4) is a conserved and essential enzyme that dephosphorylates serine and threonine residues in substrates. Despite the importance of PP4 general principles ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-02-13 | MSV000083438 | MassIVE
UnknownPervasive phenotypic effects of FBXO42 are promoted by regulation of PP4 phosphatase.
Not available
S-EPMC12909836 | biostudies-literature
UnknownNovel perspectives of target-binding by the evolutionarily conserved PP4 phosphatase.
Not available
S-EPMC7776573 | biostudies-literature
TranscriptomicsMapping and characterization of promoter-binding sites of protein phosphatase 1
Protein phosphatase 1 (PP1) is a Ser/Thr phosphatase that has been implicated in many key cellular functions including transcriptional regulation. Due to its involvement these many processes, it becomes difficult to directly link PP1 to transcriptional regulation on the chromatin level as no direct ...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-54170 | biostudies-arrayexpress
ProteomicsIdentification of phosphatases that dephosphorylate Tom6 using synthetic trap-peptides
The identification of phosphatases that dephosphorylate specific sites in proteins remains a major challenge, particularly for the major class of serine/threonine-specific phosphatases, which function as holoenzymes. Here, we report the development of synthetic trap-peptides to identify phosphatases...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-06-16 | PXD058384 | Pride
Trap-peptides Phosphatases Pfa Psy2 Pp2a Cdc55 Tom complex Protein import Pp4 Tom6 
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