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ProteomicsNeuroproteomics with Systems Biology: The proteomic landscape of adult human hypothalamus
The hypothalamus is an anatomically small, but functionally crucial region of the human brain. Normal hypothalamus functioning is central to the regulation of neuroendocrine and neurovegetative systems as well as modulation of chronobiology and behavioral aspects of the human body. Till date the hum...
ORGANISM(S): Homo sapiens (Human) 
2021-11-01 | PXD026879 | Pride
Hypothalamus Autophagy Proteomics Proteogenomics Post translational modifications Neuropeptides. Human brain Adult neurogenesis Orbitrap fusion 
ProteomicsA proteomic landscape of the spatiotemporal influence of Interleukin-33 (IL-33) in monocytes
Interleukin-33 (IL-33), a member of the IL-1 superfamily cytokines, is an endogenous danger signal and a nuclear-associated cytokine. It is one of the essential mediators of both innate and adaptive immune responses. Aberrant IL-33 signaling has been demonstrated to play a defensive role against var...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD028673 | Pride
Innate immunity Inflammation Cytokines Mass spectrometry Signaling Monocytes 
MetabolomicsMetabolomic fingerprinting of bull spermatozoa for identification of fertility signature metabolites
The objective of the study was to identify the fertility-associated metabolites in bovine spermatozoa using liquid chromatography-mass spectrometry (LC-MS). Six Holstein Friesian crossbred bulls (three high-fertile and three low-fertile bulls) were the experimental animals. Sperm proteins were isola...
2021-12-07 | MTBLS1071 | MetaboLights
ProteomicsLC-MS/MS data of Tinospora cordifolia
Tinospora cordifolia has been used for thousands of years to treat various health conditions, including neurodegenerative diseases. The study aimed to elucidate the mechanism of action and protein targets of T. cordifolia in the context of Alzheimers disease through untargeted metabolomics and netwo...
ORGANISM(S): Tinospora Cordifolia (ncbitaxon:285590) 
2024-11-04 | MSV000096283 | MassIVE
MetabolomicsDeciphering metabolomic alterations in seminal plasma of crossbred (Bos taurus X Bos indicus) bulls through comparative deep metabolomic analysis
The incidence of sub-fertility is higher in crossbred bulls compared to zebu bulls. In the present study, we analysed the metabolomic profile of seminal plasma from crossbred and zebu bulls and uncovered differentially expressed metabolites between these two breeds. Using a high-throughput LC-MS/MS-...
2021-12-22 | MTBLS1642 | MetaboLights
ProteomicsNovel Events, Gene Model Correction of Mycobacterium Avium by Proteogenomic Analysis
Mycobacterium avium is one of the prominent disease causing bacteria in humans. It causes lymphadenitis, chronic pulmonary and extrapulmonary and disseminated infections in adults, children and immunocompromised humans. M. avium has ~4,500 predicted gene models, out of which not all are identified a...
ORGANISM(S): Mycobacterium avium 104 
2023-03-17 | PXD032067 | Pride
Dia Mycobacterium avium Proteogenomics Variant calling Dda Lc-ms/ms 
ProteomicsIdentification of serum-based biomarkers in oral cancer among tobacco users
Oral cancer is the leading cancer worldwide with significant morbidity and mortality rate. Use of tobacco in form of both chewing and smoking have been known as major risk factors along with alcohol and HPV infection. Despite such knowledge, there are yet no proper screening strategy employed for sc...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD019014 | Pride
Oscc Serum proteomics Smoke Tobacco Mass spectrometry 
ProteomicsDataset of spatiotemporal influences of interleukin IL-1 family cytokine: Interleukin-33 on cellular signal transduction pathways
Interleukin-33 (IL-33) is a member of the IL-1 family of cytokines that play a central role in the regulation of immune responses. IL-33 signaling, from the early signaling events triggered by the ligand-activated receptor to result in activation of early and late signaling events, such as proteome...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD024385 | Pride
Mass spectrometry Cytokines Il-33 Monocytes 
ProteomicsPhosphoproteomic analysis of Protein Phosphatase PfPPM2/PP2C mutant of Plasmodium falciparum 3D7
PfPPM2, a protein phosphatase, plays a key role in regulating both the asexual and sexual development of the human malaria parasite P. falciparum. To understand the mechanisms by which PfPPM2 influences this process, it was essential to identify its targets or substrates within the parasite. To achi...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2025-04-08 | PXD055390 | Pride
Phosphoproteomics Plasmodium falciparum Tmt labelling Orbitrap fusion. 
ProteomicsProteomic analysis of human anterior pituitary gland
The regulation of pituitary function via the hypothalamus and via intra-pituitary connections represents a complex system. Though hormones secreted from the pituitary glands have been well studied, overall information of proteins expressed in the pituitary glands is very limited. Protein expression ...
ORGANISM(S): Homo sapiens (Human) 
2019-01-02 | PXD005819 | Pride
Adenohypophysis Anterior pituitary gland Proteomics 
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