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ProteomicsComputational Prediction, Validation and Repurposing of Existing Drug as Inhibitor of Vascular Calcification
This study aimed to identify small molecules that inhibit vascular calcification with computational approach. To examine the mechanism of calcification inhibition, proteomics analysis was performed using aorta tissue samples to clarify therapeutic target.
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD029963 | Pride
Vascular calcification Proteomics Mice Wnt signaling Drug discovery Drug repurposing 
ProteomicsApoC-III is a novel inducer of human valvular calcification
Pharmacological interventions to treat valvular calcification are not currently part of clinical guidelines. Low-density lipoprotein lowering therapies to treat calcific aortic valve disease (CAVD) failed in clinical trials. However, apolipoproteins are known promotors of atherosclerosis and may pla...
ORGANISM(S): Homo sapiens (Human) 
2020-12-14 | PXD021858 | Pride
Calcific aortic valve disease  valvular interstitial cells  fibrosis  lipids  apoc-iii 
ProteomicsCarnitine O-octanoyltransferase is a novel inducer of vascular calcification via promoting fatty acid metabolism and mitochondrial dysfunction
Objective – Vascular calcification is a critical pathology associated with increased cardiovascular event risk, but there are no FDA-approved anti-calcific therapies. We hypothesized and validated that an unbiased screening approach would identify novel mediators of human vascular calcification. Ap...
ORGANISM(S): Homo sapiens (Human) 
2021-02-26 | PXD022575 | Pride
Human primary smooth muscle cells Crot Cardiovascular calcification 
ProteomicsExtracellular Vesicles proteind in vascular calcification
Vascular Calcification (VC) is a life threatening cardiovascular complication that accounts for high death rates particularly in association with diabetes, atherosclerosis and Chronic Kidney Disease (CKD. during VC, Vascular Smooth Muscle Cells (VSMCs) undergo reprogramming into osteoblast-like cell...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-23 | PXD018169 | Pride
Type i collagen Extracellular vesicles Vascular calcification Oligogalacturonic acid 
OtherQuantitative proteomics provides new insights into chicken eggshell matrix protein functions during the primary events of mineralisation and the active calcification phase.
Data from ProteomeXchange, PXD ID: PXD001450. File: 13-3105_Gautron_7h_1_ORBI486.mzML. Published as part of J Proteomics. 2015 Jun 3. pii: S1874-3919(15)30033-6 . From the Abstract: {{i}} Eggshell is a bioceramic composed of 95% calcium carbonate mineral and 3.5% organic matrix. Its structural orga...
ORGANISM(S): Chicken 
GPM32310020586 | GPMDB
Resource Reanalysis 
ProteomicsCalcific hVIC niclosamide treatment
Niclosamide has emerged as a promising drug for cardiac valve calcification treatment. Previous study suggested niclosamide's protective effects against vascular smooth muscle cell calcification. Yet, its impact on human VICs remained unexplored. In this study, we performed global and phospho-proteo...
ORGANISM(S): Homo sapiens (Human) 
2026-10-15 | PXD047708 | Pride
Cavd Proteomics. calcification Hvic Niclosamide 
UnknownDissecting sexual dimorphism in aortic valve stenosis by proteomics.
Not available
S-EPMC12502187 | biostudies-literature
ProteomicsCrenigacestat inhibits osteogenic differentiation of human valve interstitial cells and seems promising for treatment of cardiovascular calcification
Vascular calcification is common pathology various forms of which presented in the half of humans. Calcific aortic valve disease (CAVD) is one of the most dangerous forms of vascular calcification. Despite high mortality there is no target therapy against CAVD. Thus, we tested crenigacestat (LY30394...
ORGANISM(S): Homo sapiens (Human) 
2022-10-04 | PXD029632 | Pride
Valve intersticial cells Timstof pro Vascular calcification Ly3039478 Notch inhibitors Crenigacestat Calcific aortic valve disease Shotgun proteomics 
ProteomicsMitochondrial extracellular vesicles promote aortic valve calcification via carnitine O-octanoyltransferase
Calcific aortic valve disease (CAVD) is a leading cause of cardiovascular morbidity and mortality with no effective medical therapy. We previously identified carnitine O-octanoyltransferase (CROT) as a mediator of mitochondrial dysfunction and vascular calcification. However, its role in CAVD remain...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-05-13 | PXD072508 | Pride
Mitochondrial extracellular vesicles Aortic valve calcification Mitochondria Valvular interstitial cells Lc-ms/ms 
ProteomicsProteomic characterization of extracellular vesicles (EVs) released by primary human vascular smooth muscle cells (VSMCs) under calcification stress
Vascular calcification (VC) is a strong predictor of cardiovascular risk, particularly in chronic kidney disease (CKD) patients, associated with increased vascular stiffness, pulse pressure, left ventricular hypertrophy and atherosclerotic plaque burden [1]. VC is currently accepted as a highly cont...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044045 | Pride
Human  vascular smooth muscle cells (vsmcs)  vascular calcification  lc-msms 
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