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ProteomicsA chaperone-assisted mechanism of outer mitochondrial membrane TOM70 insertion protective against diet-induced obesity
Outer mitochondrial membrane (OMM) proteins communicate with the cytosol and other organelles including the endoplasmic reticulum (ER). This communication is important in thermogenic adipocytes to increase energy expenditure that controls body temperature and weight. However, the regulatory mechanis...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-02 | PXD054182 | Pride
Obesity Mitochondria Ppid Tom70 Perk Mitochondrial transport Chaparone 
ProteomicsA chaperone-assisted mechanism of outer mitochondrial membrane TOM70 insertion protective against diet-induced obesity
Outer mitochondrial membrane (OMM) proteins communicate with the cytosol and other organelles including the endoplasmic reticulum (ER). This communication is important in thermogenic adipocytes to increase energy expenditure that controls body temperature and weight. However, the regulatory mechanis...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-02 | PXD055263 | Pride
Mitochondria Tom70 Chaparone Obesity 
TranscriptomicsBrown fat-specific YY1 deficiency effect on subcutaneous white adipose tissue
Analysis of visceral white adipose tissue (EWAT) from Yin Yang 1 adipose-specific knockout mice exposed to cold (4ºC) for 4 days. Control mice YY1flox/flox versus YY1flox/flox; Adiponectin Cre were cold exposed for 4 days.
ORGANISM(S): Mus musculus 
2015-11-10 | E-GEOD-70562 | biostudies-arrayexpress
TranscriptomicsBrown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity [BAT]
Analysis of brown adipose tissue from Yin Yang 1 (YY1) brown fat specific knockout mice fed a high fat diet for 3 months. YY1 deficiency in brown adipose tissue leads to strong thermogenic deficiency. The goal was to identify the genes controlled by YY1 responsible of brown fat defective function. C...
ORGANISM(S): Mus musculus 
2015-11-10 | E-GEOD-68429 | biostudies-arrayexpress
TranscriptomicsBrown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity [IWAT]
Analysis of subcutaneous adipose tissue (IWAT) from Yin Yang 1 brown fat specific knockout mice fed a high fat diet for 2 weeks. The goal was to identify a gene signature of IWAT browning in YY1 mutant mice. Control mice YY1flox/flox versus YY1flox/flox; Ucp1Cre were fed a high fat diet for 2 weeks
ORGANISM(S): Mus musculus 
2015-11-10 | E-GEOD-68382 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse skeletal muscle
We generated skeletal muscle-specific knockout mice lacking the transcription factor Yin Yang 1 (YY1) and analyzed expression patterns in the skeletal muscle these mice. We used microarrays to detail the global programme of gene expression regulated by YY1. Wild type or knockout mice at 6 months wer...
ORGANISM(S): Mus musculus 
2012-06-29 | E-GEOD-39009 | biostudies-arrayexpress
ProteomicsProteomic analysis of U2OS cells treated with the dihydroorotate dehydrogenase (DHODH) inhibitor Brequinar
The mitochondrial respiratory chain assembles into higher order complexes termed supercomplexes (SCs) under certain physiological or metabolic stimuli. A small molecule screen developed by the lab identified DHODH inhibitors as potent activators of SC assembly in cancer cells. To investigate the pro...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD023882 | Pride
Respirasome Mitochondria Supercomplexes Nucleotides Dihydroorotate dehydrogenase Pyrimidines 
ProteomicsDefective NADPH Production in Mitochondrial Disease Complex I Causes Inflammation and Cell Death
Electron transport chain (ETC) defects occurring from mitochondrial disease mutations compromise ATP synthesis and render cells vulnerable to nutrient and oxidative stress conditions. This bioenergetic failure is thought to underlie pathologies associated with mitochondrial diseases. However, the pr...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018839 | Pride
Human Mitochondria Tmt Nature communication manuscript: ncomms-19-24220b 
ProteomicsProteomic analysis of whole brains from Ndufs4-/- mice treated with doxycycline
Mice with mitochondrial complex I deficiency (Ndufs4-/-) suffer from severe energy impairment primarily affecting the brain and die at P55. A small molecule screen developed by our lab using cells harboring human mitochondrial disease mutations identified antibiotics targeting mitochondrial translat...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD022860 | Pride
Mitochondrial translation Mouse brain Mitochondrial disease Tetracycline 
Proteomicssuppression of PPARGC1A causes collateral sensitivity to HMGCR-inhibitor within BRAFi-treatement resistant melanoma
We aimed to identify the potential proteins as a collateral vulnerability within PGC1a-suppressed BRAF-inhibitor resistant melanomas, and the potential mechanisms behind this including their abundancy and cellular distribution.
ORGANISM(S): Homo sapiens (Human) 
2023-06-09 | PXD041952 | Pride
Melanoma statin ppargc1a statin 
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