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ProteomicsMild acid elution and MHC immunoaffinity chromatography reveal similar albeit not identical profiles of the HLA immunopeptidome
To understand and treat immunology-related diseases, a comprehensive, unbiased characterization of major histocompatibility complex (MHC) peptide ligands is of key importance. Preceding the analysis by mass spectrometry, MHC peptide ligands are typically isolated by MHC immunoaffinity chromatography...
ORGANISM(S): Homo sapiens (Human) 
2020-11-11 | PXD012771 | Pride
Mhc immunoaffinity chromatography Cid Post-translational modification Hla ligandome Mild acid elution Cysteinylation Mhc bound peptides 
ProteomicsMapping the HLA ligandome of Colorectal Cancer Reveals an Imprint of Malignant Cell Transformation
Immunopeptidome analysis of colorectal adenocarcinoma tissues as well as adjacent benign tissues was performed to characterize the natural HLA class I and class II presented ligandome represented in the context of malignancy as well as in benign tissue of the colon.
ORGANISM(S): Homo sapiens (Human) 
2019-03-12 | PXD009602 | Pride
Neoplasia Cancer Hla-ligandomics Hla Colorectal adenocarcinoma Colon cancer Peptide Hla-restricted peptide Hla-ligand Colon 
ProteomicsT cells of colorectal cancer patients’ stimulated by neoantigenic and cryptic peptides better recognize autologous tumor cells
Immunopeptidome analysis of patient-derived colorectal cancer cell lines HROC113 and HROC285 T0 M2 from the HROC collection [Mullins et al. Cancers (Basel). 2019;11(10):1520. doi: 10.3390/cancers11101520] was performed to characterize the natural HLA class I presented ligandome in native as well as ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037587 | Pride
Hla-presented peptides  neoepitope Colorectal cancer Human Hla class i Antigen presentation Lc-msms 
ProteomicsThe immunopeptidomic landscape of ovarian carcinoma
Immunopeptidome analysis of ovarian carcinoma tissues was performed to characterize the HLA class I and class II presented ligandome of this malignancy.
ORGANISM(S): Homo sapiens (Human) 
2017-11-02 | PXD007635 | Pride
Hla Ovarian cancer Immunopeptidome 
ProteomicsThe HLA-Ligand-Atlas. A resource of natural HLA ligands presented on benign tissues
The human leukocyte antigen (HLA) complex regulates the adaptive immune response by showcasing the intracellular and extracellular protein content to the immune system. T cells recognize these HLA-presented peptides as self or foreign and can elicit an immune response. In this work, we describe the...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-31 | MSV000096271 | MassIVE
ProteomicsA Non-interventional Clinical Trial Assessing Immune Responses After Radiofrequency Ablation of Liver Metastases From Colorectal Cancer
HLA ligandome analysis of colorectal adenocarcinoma tissues obtained from liver metastases (mCRC) as well as adjacent non-malignant liver tissues was performed to characterize the natural HLA class I and class II presented ligands on both mCRC and adjacent liver tissue.
ORGANISM(S): Homo sapiens (Human) 
2019-12-11 | PXD015947 | Pride
Neoplasia Cancer Hla-ligandomics Hla Colorectal adenocarcinoma Colon cancer Peptide Hla-restricted peptide Hla-ligand Colon Metastasis 
ProteomicsMulti-omics discovery of exome-derived neoantigens in hepatocellular carcinoma
HLA class I ligandome dataset obtained from hepatocellular carcinoma (HCC) as well as corresponding adjacent benign liver tissue (n=16) characterizing respective HLA immunoprecipitates. Additionally, from a subset of the mentioned HCC/ adjacent benign liver samples datasets gained from shotgun prote...
ORGANISM(S): Homo sapiens (Human) 
2019-05-06 | PXD013057 | Pride
Hla Hla ligandomics Multi-omics Peptide prediction Mass spectrometry Personalized medicine Immunoinformatics Next-generation sequencing Immunotherapy Hepatocellular carcinoma Neoantigen Liver cancer 
ProteomicsHCMV deletion models enable the identification of physiologically relevant T-cell epitopes
In healthy individuals, immune control of persistent human cytomegalovirus (HCMV) infection is effectively mediated by virus-specific CD4+ and CD8+ T cells. However, identification of the repertoire of T-cell specificities for HCMV is hampered by the immense protein coding capacity of this betaherpe...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus 
2019-11-20 | PXD013120 | Pride
Hla Hla ligandomics T-cell epitopes Human cytomegalovirus Immunoevasin deletion Immunotherapy Mhc affinity prediction 
ProteomicsThe HLA-Ligand-Atlas. A resource of natural HLA ligands presented on benign tissues
The human leukocyte antigen (HLA) complex regulates the adaptive immune response by showcasing the intracellular and extracellular protein content to the immune system. T cells recognize these HLA-presented peptides as self or foreign and can elicit an immune response. In this work, we describe the...
ORGANISM(S): Homo sapiens (Human) 
2021-04-16 | PXD019643 | Pride
Human Hla Benign tissues Immunopeptidomics 
ProteomicsThe HLA-Ligand-Atlas. A resource of natural HLA ligands presented on benign tissues
A use case of the benign HLA-Ligand-Atlas is the prioritization of tumor-associated targets for e.g. peptide vaccination. Based on three glioblastoma samples, we illustrated how many of these peptides are covered in the benign dataset. The experimental and computational workflow for the isolation an...
ORGANISM(S): Homo sapiens (Human) 
2021-04-16 | PXD020186 | Pride
Human Hla Glioblastoma Immunopeptidomics 
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