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MetabolomicsChanges in lipid profiles of epileptic mouse model

INTRODUCTION: Approximately 1% of the world's population is impacted by epilepsy, a chronic neurological disorder characterized by seizures. One-third of epileptic patients are resistant to AEDs, or have medically refractory epilepsy (MRE). One non-invasive treatment that exists...

2022-01-06 | MTBLS1432 | MetaboLights
TranscriptomicsComparative Genomic Analysis of PhoP Regulon in S. Typhi and S. Typhimurium
Transcriptional profiling of three sequenced S. enterica strains: S. Typhimurium LT2, S. Typhi CT18, and S. Typhi Ty2 in PhoP-inducing and non-inducing conditions in vitro, and compared these results to profiles of phoP-/Q- mutants derived from S. Typhimurium LT2 and S. Typhi Ty2. Two-condition expe...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 
2010-05-06 | E-GEOD-17670 | biostudies-arrayexpress
ProteomicsAccessory subunits are integral for assembly and function of human mitochondrial complex I
Complex I (NADH:ubiquinone oxidoreductase) is the first enzyme of the mitochondrial respiratory chain (RC) and is composed of 44 different subunits in humans, making it one of the largest known multi-subunit membrane protein complexes. Complex I exists in supercomplex forms with RC complexes III and...
ORGANISM(S): Homo sapiens (Human) 
2016-09-26 | PXD004666 | Pride
Ap-ms Nadh Talen Hek293t Crispr Oxphos Lc-ms Silac Mitochondria Human 
MetabolomicsMolecular basis for multidrug efflux by an anaerobic-associated RND transporter

Bacteria can resist antibiotics and toxic substances within demanding ecological settings, such as low oxygen, extreme acid, and during nutrient starvation. MdtEF, a proton motive force-driven efflux pump from the resistance-nodulation-cell division (RND) superfamily, is upregulated in these cond...

2025-09-26 | MTBLS13050 | MetaboLights
TranscriptomicsFNR- vs WT in anoxic conditions
Salmonella enterica var. Typhimurium (S. Typhimurium) is a Gram-negative, facultative intracellular pathogen that infects the intestinal tracts of humans and animals. In the host, S. Typhimurium encounters a wide range of oxygen concentrations going from oxic conditions in the stomach to near anoxic...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2010-07-01 | E-GEOD-3657 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of normal and cancerous human breast samples
To assess changes in DNA methylation state associated with breast cancer we analyzed DNA from normal and cancerous breast specimens on CpG islands microarray using methylation-sensitive enzyme McrBC for target preparation. Cy3 was used for McrBC cut sample, Cy5 was used for reference Mock sample.
ORGANISM(S): Homo sapiens 
2006-11-03 | E-MEXP-881 | biostudies-arrayexpress
UnknownAdverse Childhood Experiences and Hospital-Treated Self-Harm.
Not available
S-EPMC6026473 | biostudies-literature
ProteomicsDIA proteomic analysis of unstimulated murine bone marrow derived macrophages from WT, Nrf2 KO and Keap1 KD cells
Unstimulated murine bone marrow derived macrophages cultured in L92 media from WT (4 biological replicates), Nrf2 KO (3 biological replicates) and Keap1 KD BMDM (3 biological replicates) were processed and analysed utilising DIA (label free) proteomic analysis. The Nrf2 KO mouse (DOI: 10.1006/bbrc.1...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-01 | PXD030455 | Pride
Dia Keap1 Nrf2 Macrophages Bmdm Murine 
MetabolomicsDivergent relationships between faecal microbiota and metabolome following distinct antibiotic-induced disruptions
The intestinal microbiome plays an essential role in regulating many aspects of host physiology, and its disruption through antibiotic exposure has been implicated in the development of a range of serious pathologies. The complex metabolic relationships that exist between members of the intestinal m...
2017-03-03 | MTBLS422 | MetaboLights
TranscriptomicsMethylation profiling of normal and cancerous breast cells from human patients and cell lines in a 125 kB region of the HOXA cluster
To evaluate DNA methylation profile associated with breast cancer in 125 kB region of HOXA cluster we analyzed DNA from normal cancerous breast specimens and cell lines. Analysis was performed on the tiling array covering entire HOXA region with 500bp resolution. Immunoprecipitation with anti-methyl...
ORGANISM(S): Homo sapiens 
2006-11-03 | E-MEXP-880 | biostudies-arrayexpress
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