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ProteomicsPulldown GST-SH3 domains of Endophilin and rat brain lysates
Pulldown experiments using GST-SH3 domains from hman Endophilin A1, A2 and A3 and rat brain lysates
ORGANISM(S): Rattus norvegicus (Rat) 
2018-08-06 | PXD010090 | Pride
Pulldown Endophilin Rat brain lysates 
MetabolomicsLocal and systemic metabolic alterations in brain, plasma, and liver of rats in response to aging and ischemic stroke, as detected by nuclear magnetic resonance (NMR) spectroscopy
Cerebral ischemia and aging induce local and systemic effects, and impact severity of stroke outcome. We performed comprehensive metabolic profiling to detect metabolites in brain, plasma, and liver as a function of aging and ischemia/reperfusion (IR). Ischemic stroke was induced by middle cerebral ...
2019-02-01 | MTBLS516 | MetaboLights
ProteomicsRat, male, brain, medial amygdala, LC-MSMS
Social isolation poses a severe mental and physiological burden on humans. Most animal models that investigate this effect are based on prolonged isolation, which does not mimic the milder conditions experienced by people in the real world. Here we show that in the medial amygdala, a brain structure...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-11-03 | PXD026871 | Pride
Lc-msms Brain Rat Medial amygdala Social isolation 
ProteomicsPulldown of P180/RRBP1 interacting protein
P180/RRBP1 is an integral ER-resident protein known to be involved in mRNA binding and translation at the ER. We found that P180/RBBP1 is enriched in neuronal axons. To acquire more knowledge about its interactome and confirmation that P180/RRBP1 is interacting with ribosomes, we performed an unbias...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2024-10-14 | PXD050948 | Pride
Brain P180/rrbp1 Hek293 
UnknownIntrastriatal injection of Parkinson's disease intestine and vagus lysates initiates α-synucleinopathy in rat brain.
Not available
S-EPMC9814765 | biostudies-literature
ProteomicsMagnolia officinalis (L.) Bark Extract Counteracts Oxidative Brain In-jury: A Proteomic Investigation into Neuroprotective Mechanisms
Neurodegenerative diseases involve progressive neuronal loss associated with oxidative stress (OS) and inflammation. Given the limited efficacy of current therapies, natural compounds with multitarget neuroprotective potential are of growing interest. In this study, we investigated the neuroprotecti...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-05-25 | PXD075711 | Pride
Rat Label-free proteomics Magnolia officinalis (l.) Phytochemicals Age-related disor-ders Oxidative stress Neuroprotection Lc-hrms/ms 
UnknownProtein purification and cloning of diacylglycerol lipase from rat brain.
Not available
S-EPMC4892392 | biostudies-literature
ProteomicsNuclear Paxillin Modulates Alternative Splicing Programs in Neurons during Sensitive Periods of Brain Development
During sensitive postnatal periods, brain neural circuits undergo significant refinement coincident with widespread neuronal alternative splicing events in which hundreds of genes alter their splice site selection to generate isoforms essential for synaptic plasticity. Here, we reveal that neuronal ...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-08-08 | PXD060131 | Pride
Neuron Brain Rat Cortex Paxillin Alternative splicing 
TranscriptomicsIdentification of Neuronal RNA Targets of TDP-43-Containing Ribonucleoprotein Complexes
We identify the RNA targets of TAR DNA-binding protein 43 (TDP-43) from cortical neurons by RNA immunoprecipitation followed by deep sequencing (RIP-seq). We identify 4352 highly enriched RNA targets of TDP-43. We determined that the canonical TDP-43 binding site (TG)n was 55.1-fold enriched in our ...
ORGANISM(S): Rattus norvegicus 
2010-11-04 | E-GEOD-25032 | biostudies-arrayexpress
ProteomicsEndocytic Turnover of Endothelial Cell-Membrane Proteins as a Driver of Blood Brain Barrier Specialization and Dysfunction
The blood-brain barrier (BBB), formed primarily by specialized brain endothelial cells (BEC), exerts essential functions for proper brain activity, including nutrient transport, signal transduction, immune cell transmigration and pathogen restriction. While these functions are known to be regulated ...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-05-15 | PXD067112 | Pride
Blood-brain barrier Brain endothelial cells Endocytic turnover rate 
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