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ProteomicsAPOE-Dependent Molecular Abnormalities in the Cerebrovasculature of Autopsied Alzheimer Disease Brain Tissue
Cerebrovascular dysfunction is a hallmark feature of Alzheimer's disease (AD). One of the greatest risk factor for AD is the apolipoprotein E4 (E4) allele. APOE4 genotype has been shown to negatively impact on perivascular amyloid clearance, however, its direct influence along with the other APOE va...
ORGANISM(S): Homo sapiens (Human) 
2021-03-23 | PXD023340 | Pride
Alzheimer’s disease Proteomics Apoe Mass spectrometry Endothelial cells Cerebrovasculature Mural cells Perivascular cells 
ProteomicsUnbiased proteomic analyses of plasma and brain tissue from TBI and AD mouse models II
The relationship between repetitive mild traumatic brain injury (r-mTBI) and Alzheimer’s disease (AD) is well-recognized. However, the precise nature of how r-mTBI leads to or precipitates AD pathogenesis is currently not understood. Part A: Plasma biomarkers potentially provide non-invasive tools ...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-11 | PXD010664 | Pride
Alzheimer’s disease Proteomics Htau Ps1/app Mild-tbi Brain profiles Plasma biomarker 
ProteomicsUnbiased proteomic analyses of plasma and brain tissue from TBI and AD mouse models
The relationship between repetitive mild traumatic brain injury (r-mTBI) and Alzheimer’s disease (AD) is well-recognized. However, the precise nature of how r-mTBI leads to or precipitates AD pathogenesis is currently not understood. Part A: Plasma biomarkers potentially provide non-invasive tools...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-22 | PXD010602 | Pride
Ad Hippocampus Tmt Plasma Cortex Tbi 
ProteomicsVentriculomics analyses of autopsy AD tissue
Very little studies have explored the role played by the specialized choroid plexus epithelial cells and the ependymal cells that line the ventricles. In normal and pathological (AD) ageing, reports of alterations in the blood brain CSF barrier (BCSFB) integrity and membrane transporters, accompanie...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD012059 | Pride
Human Lateral ventricules Protein Lcms 
UnknownPivotal Evaluation of an Artificial Intelligence System for Autonomous Detection of Referrable and Vision-Threatening Diabetic Retinopathy.
Not available
S-EPMC8593763 | biostudies-literature
UnknownA variant in MCF2L is associated with osteoarthritis.
Not available
S-EPMC3169824 | biostudies-literature
UnknownEffect of Sickle Cell Trait and APOL1 Genotype on the Association of Soluble uPAR with Kidney Function Measures in Black Americans.
Not available
S-EPMC7863645 | biostudies-literature
UnknownAssociation of mRNA Vaccination With Clinical and Virologic Features of COVID-19 Among US Essential and Frontline Workers.
Not available
S-EPMC9579910 | biostudies-literature
UnknownEffectiveness of Iodophor vs Chlorhexidine Solutions for Surgical Site Infections and Unplanned Reoperations for Patients Who Underwent Fracture Repair: The PREP-IT Master Protocol.
Not available
S-EPMC7139274 | biostudies-literature
UnknownSimvastatin in Critically Ill Patients with Covid-19.
Not available
S-EPMC10755839 | biostudies-literature
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