Roberts syndrome (RBS) is a human developmental disorder caused by mutations in the cohesin acetyltransferase ESCO2. We previously reported that mTORC1 was inhibited and overall translation was reduced in RBS cells. Treatment of RBS cells with L-leucine partially rescued mTOR function and protein sy...
Roberts2010 - Genome-scale metabolic network
of Clostridium thermocellum (iSR432)
This model is described in the article:
Genome-scale metabolic
analysis of Clostridium thermocellum for bioethanol
production.
Roberts SB, Gowen CM, Brooks JP,
Fong SS.
BMC Syst Biol 2010; 4:...
A prospective observational pilot study from right-sided colorectal cancer (RCRC) patients was performed at Imperial College London NHS Trust, UK. Treatment naïve patients undergoing elective resectional surgery for primary RCRCs were recruited. Fresh intra-luminal fecal samples were obtained at ...
The adult data set. The pathogenesis of multi-organ dysfunction associated with severe acute SARS-CoV-2 infection remains poorly understood. Endothelial damage and microvascular thrombosis have been identified as drivers of COVID-19 severity, yet the mechanisms underlying these processes remain elus...
Analysis of plasma from adult and pediatric COVID-19 patients via untargeted and targeted proteomics reveals activation in complement and coagulation pathways as common elements in both populations
The pig is important for agriculture and as an animal model in human and veterinary medicine, yet, despite over 20 years of effort, it has proved a difficult species from which to generate pluripotent stem cells analogous to those derived from mouse embryos. Here we report the production of LIF-depe...
Oyster larvae were reared at two different temperatures (23C and 29C) over 13 days, and 40-50 larvae were sampled on days 3, 5, 7, 9, 11, and 13 for proteomics.
Aging of skeletal muscle tissue is characterized by loss of metabolic and contractile competence. It is thought that this phenomenon is driven via extrinsic and intrinsic factors. In order to identify age-dependent changes intrinsic to the muscle cell, microarray transcriptional profiles and measure...
The oocyte-to-embryo transition (OET) is thought to be mainly driven by post-transcriptional gene regulation. However, expression of both RNAs and proteins during the OET has not been comprehensively assayed. Furthermore, specific molecular mechanisms that regulate gene expression during OET are lar...
