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TranscriptomicsThe gene encoding the hematopoietic stem cell regulator CCN3 (NOV) is under direct cytokine control through the transcription factors STAT5a/b.
Cytokines control the biology of hematopoietic stem and progenitor cells in part through the transcription factors STAT5a/b. CCN3/NOV has been reported as a positive regulator of hematopoietic stem and progenitor cells. We report microarray analyses of Lineage- Sca-1+ c-Kit+ (KSL) cells in the pre...
ORGANISM(S): Mus musculus 
2010-08-25 | E-GEOD-20684 | biostudies-arrayexpress
ProteomicsIFITM3 BioID Interactomes in B-ALL and MCL
To determine the roles of membrane associated IFITM3 in BCR-signalling in B-cell malignancies we expressed N-terminal BirA-IFITM3-Y20E fusion or BirA-EV control in patient derived B-ALL cells (PDX2) and Jeko1 Mantle cell lymphoma (MCL) cells. Additionally to examine the role of PIP3 binding residues...
ORGANISM(S): Homo sapiens (Human) 
2020-12-18 | PXD020697 | Pride
Human b-all mcl b-cells 
ProteomicsThe B Cell Repertoire in Multiple Sclerosis Reveals Molecular Mimicry between EBNA1 and GlialCAM
This data set contains the mass spectrometry raw files for the paper The B Cell Repertoire in Multiple Sclerosis Reveals Molecular Mimicry between EBNA1 and GlialCAM. In multiple sclerosis (MS) intrathecal B lymphocytes are directly involved in inflammation and secrete oligoclonal immunoglobulin. Ho...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-02-11 | MSV000086842 | MassIVE
ProteomicsBeta-catenin interacting proteins in BCR-ABL1+ B-ALL cells [exp1]
Identification of beta-catenin interacting proteins via affinity purification with anti-beta-catenin antibody or IgG control in BCR-ABL1 transformed murine pre-B cells with induced beta-catenin activation via CTNNB1 exon3 fl/fl + Cre.
ORGANISM(S): Mus musculus (Mouse) 
2025-08-13 | PXD067271 | Pride
Pre-b B-cell 
ProteomicsBeta-catenin interacting proteins in BCR-ABL1+ B-ALL cells [exp2]
Identification of beta-catenin interacting proteins via affinity purification with anti-beta-catenin antibody or IgG control in BCR-ABL1 transformed murine pre-B cells with induced beta-catenin activation via CTNNB1 exon3 fl/fl + Cre.
ORGANISM(S): Mus musculus (Mouse) 
2025-08-13 | PXD067314 | Pride
B-all 
ProteomicsGlobal phospho-proteomics analysis of the effect of CD25 KO in precursor and mature B-cell
To assess the effect of CD25 (Il2ra) knockout on signaling in pre-B leukemia, pre-B cells from CD25-floxed mouse bone marrow were grown ex-vivo with IL-7 and transformed with BCR-ABL1, before treatment with 4-OHT to induce CD25 KO. Phosphoproteomics was performed and differential phosphosites analys...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD038996 | Pride
B-cell pre-b cd25 il2ra phospho-proteomics 
ProteomicsBeta-catenin interacting proteins in WT and Ikzf1/3-KO BCR-ABL1 transformed B-ALL
Identification of beta-catenin interacting proteins via affinity purification with anti-beta-catenin antibody or IgG control in WT (NTC control) or Ikzf1/Ikzf3-KO (dual CRISPR KO) BCR-ABL1 transformed murine pre-B cells with CTNNB1 activation via a Ctnnb1 Ex3 fl/fl + Ert2Cre model.
ORGANISM(S): Mus musculus (Mouse) 
2025-08-13 | PXD067318 | Pride
Pre-b B-cell 
ProteomicsBioID of CD25 mutants in B-cell malignancies
CD25-dificient patient-derived PDX2 B-ALL cells and Jeko1 MCL cells with CRISPR-Cas9-mediated gene deletion were reconstituted with wild-type CD25 (S268) or CD25 carrying S268A mutant (A268) with C-terminal BirA (engineered biotin ligase) and selected by puromycin for 3 days. BirA expressing constru...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD035989 | Pride
Lc-msms B-all B-cell Cd25 Mcl Bioid Il2ra 
TranscriptomicsSingle cell RNA-seq of hemagglutinin specific B cells after influenza virus infection: VDJ data
Understanding dynamics of antigen specific B cell responses and link between BCR and B cell differentiation is crucial for our ability to direct immune responses and to generate memory and plasma cells responses to protective targets. Here we have infected mice with IAV-PR8 and sacrificed them at di...
ORGANISM(S): Mus musculus 
2021-06-22 | E-MTAB-9478 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-seq of hemagglutinin specific B cells after influenza virus infection: gene expression data
Understanding dynamics of antigen specific B cell responses and link between BCR and B cell differentiation is crucial for our ability to direct immune responses and to generate memory and plasma cells responses to protective targets. Here we have infected mice with IAV-PR8 and sacrificed them at di...
ORGANISM(S): Mus musculus 
2021-06-22 | E-MTAB-9491 | biostudies-arrayexpress
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