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MetabolomicsDiel metabolomics analysis of a hot spring chlorophototrophic microbial mat leads to new hypotheses of community member metabolisms
Dynamic environmental factors such as light, nutrients, salt, and temperature continuously affect chlorophototrophic microbial mats, requiring adaptive and acclimative responses to stabilize composition and function. Quantitative metabolomics analysis can provide insights into metabolite dynamics fo...
2024-02-23 | MTBLS187 | MetaboLights
ProteomicsStructure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex, and the Regulation of Transcription
MedPIC: Crosslinking-MS of 54 subunit pre-initiation complex from yeast. MedPolII: Crosslinking-MS of 33 subunit Mediator + polII complex from yeast.
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2016-08-02 | MSV000080013 | MassIVE
ProteomicsInsulin Resistance in a Type 1 Diabetes Rat Model
A automated 32-plex cPILOT chemical labeling strategy was utilized to identify proteome changes in type 1 diabetes in rats. We utilized an Orbitrap Fusion Lumos mass spectrometer to analyze 8 fractions in technical triplicates where proteins were quantified using Tandem Mass Tag pro reagents (16-ple...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-05-26 | PXD033761 | Pride
Multiplexing Type 1 diabetes Insulin resistance Cpilot 
UnknownStructural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors.
Not available
S-EPMC8341910 | biostudies-literature
ProteomicsKefir peptide profiling - Peptidomic analysis reveals proteolytic activity of kefir microorganisms on bovine milk proteins
This study examines the proteolytic activity of the kefir grains (a combination of bacteria and yeast) on bovine milk proteins. SDS-PAGE analysis reveals substantial digestion of milk proteins by the kefir grains in comparison with control samples. Mass spectrometric analysis reveals that the kefir ...
ORGANISM(S): Bos taurus (Bovine) 
2016-05-09 | PXD001826 | Pride
Kefir Peptide Protein Peptidomic Milk 
ProteomicsMitochondrial microproteins link metabolic cues to respiratory chain biogenesis
Electron transport chain (ETC) biogenesis is tightly coupled to energy levels and availability of ETC subunits. Coenzyme Q: cytochrome c oxidoreductase (complex III or CIII) occupies a central position in the ETC, receiving electrons from diverse fuel sources to control the ubiquinol:ubiquinone (CoQ...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-25 | PXD030258 | Pride
Metabolism Sep Mitochondria Oxphos Micropeptides 
ProteomicsSodium carbonate extraction mass spectrometry reveals novel steps in mitochondrial respiratory chain complex III assembly
Mitochondria are complex organelles containing 13 proteins encoded by mitochondrial DNA and over 1000 proteins encoded on nuclear DNA. Many mitochondrial proteins are associated with the inner or outer mitochondrial membranes, either peripherally or as integral membrane proteins, while others reside...
ORGANISM(S): Homo sapiens (Human) 
2022-03-23 | PXD028935 | Pride
Proteomic analysis Mitochondria Oxphos (oxidative phosphorylation) Carbonate extraction Respiratory chain assembly Membrane protein 
ProteomicsSodium valproate is protective in a transgenic zebrafish model of Machado Joseph disease
The neurodegenerative disease Machado Joseph disease (MJD, also known as spinocerebellar ataxia-3) is a fatal disease that impairs control and co-ordination of movement. MJD is caused by expansion of a trinucleotide (CAG) repeat region within the ATXN3 gene, encoding a long polyglutamine (polyQ) reg...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2021-08-23 | PXD009612 | Pride
Ataxin-3 Label-free quantitative proteomics Machado joseph disease Polyq Zebrafish 
ProteomicsProteomics reveals a fibre-type specific mitochondrial remodelling with moderate- but not very high-intensity training
Methods for studying mitochondrial adaptations in skeletal muscle have mostly used whole-muscle samples, where results may be confounded by the presence of a mixture of type I and II skeletal muscle fibres. In this project, we utilised the latest Mass spectrometry (MS) techniques to provide new insi...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD036010 | Pride
Exercise Proteomics Training Single fibre Fibre type 
UnknownEffect of Flavonoid Supplementation on Alveolar Bone Healing-A Randomized Pilot Trial.
Not available
S-EPMC7560062 | biostudies-literature
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