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ProteomicsAsparagine hydroxylation is likely to be a reversible post-translational modification
Amino acid hydroxylation is a common post-translational modification, which generally regulates protein interactions or adds a functional group that can be further modified. Such hydroxylation is currently considered irreversible, necessitating the degradation and re-synthesis of the entire protein ...
ORGANISM(S): Hordeum vulgare (Barley) 
2020-03-23 | PXD013116 | Pride
Lc-ms/ms Hydroxylation Hypoxia Ptm 
ProteomicsPHD3 and FIH substrates cluster in distinct signalling pathways
Amino acid hydroxylation is a common post-translational modification which regulates intra and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate (2OG) dependent enzymes and although the biochemistry is well understood, until now only a few su...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080766 | MassIVE
ProteomicsGrowth cone localization of the mRNA encoding a chromatin regulator modulates neurite outgrowth
Neurons exploit local mRNA translation and retrograde transport of transcription factors to regulate gene expression in response to signaling events at distal neuronal ends. Whether epigenetic factors could also be involved in such regulation is not known. We report that the mRNA encoding the HMGN5 ...
ORGANISM(S): Mus musculus (Mouse) 
2015-04-17 | PXD001070 | Pride
Hmgn5 Neuronal development Chromatin regulation 
ProteomicsPHD3 and FIH substrates cluster in distinct signalling pathways
Amino acid hydroxylation is a common post-translational modification which regulates intra and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate (2OG) dependent enzymes and although the biochemistry is well understood, until now only a few su...
ORGANISM(S): Homo sapiens (Human) 
2016-03-30 | PXD001085 | Pride
Mapk6 Dmog Ripk4 Erk3 Hypoxia Hydroxylases 
ProteomicsHypoxia decreases the pathogenicity of Pseudomonas aeruginosa by reducing expression of multiple virulence factors.
Hypoxia is a feature of the microenvironment during P. aeruginosa infection in several disease states. We confirm that the pathogenicity of P. aeruginosa derived from sites of acute infection is higher than those derived from sites of chronic infection. Hypoxia attenuated the pathogenicity of acute ...
ORGANISM(S): Pseudomonas aeruginosa str. E2UoS 
2017-06-06 | PXD004421 | Pride
Hypoxia Pseudomonas aeruginosa 
ProteomicsDynamic partitioning of branched-chain amino acids- derived nitrogen supports renal cancer progression
Metabolic reprogramming is critical for tumor initiation and progression. However, the exact impact of specific metabolic changes on cancer progression is poorly understood. Here, we integrate multimodal analyses of primary and metastatic clonally-related clear cell renal cancer cells (ccRCC) grown ...
ORGANISM(S): Homo sapiens (Human) 
2022-11-09 | PXD037464 | Pride
Metabolism Renal cancer 
UnknownThe effects of red LED light on pig sperm function rely upon mitochondrial electron chain activity rather than on a PKC-mediated mechanism.
Not available
S-EPMC9585505 | biostudies-literature
MetabolomicsDynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression

Metabolic reprogramming is critical for tumor initiation and progression. However, the exact impact of specific metabolic changes on cancer progression is poorly understood. Here, we integrate multimodal analyses of primary and metastatic clonally-related clear cell renal cancer cells (ccRCC) gro...

2022-12-08 | MTBLS5615 | MetaboLights
UnknownThe Transcription Factor FEZF1, a Direct Target of EWSR1-FLI1 in Ewing Sarcoma Cells, Regulates the Expression of Neural-Specific Genes.
Not available
S-EPMC8616448 | biostudies-literature
TranscriptomicsTranscriptome profiling by microarray of Caenorhabditis elegans MT2124 x CB4856 RILs used for eQTL mapping
We crossed the MT2124 strain carrying the let-60 (n1046) gain of function mutation with the wild-type strain CB4856. From this cross a panel of mutation introgression recombinant inbred lines (miRILs) was generated. Using this population, the influence of genetic variation on the the let-60 (gf) mut...
ORGANISM(S): Caenorhabditis elegans 
2017-07-21 | E-MTAB-5856 | biostudies-arrayexpress
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