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ProteomicsQuantifying extracellular matrix turnover in human lung scaffold cultures
Tissue engeneering using biological scaffolds are a promising technique for solving the shortage of donor organs for patients suffering of end stage organ faliure. We introduced stable isotope labeling with amino acids in a tissue culture setting, which enabeled us to distinguish between the biologi...
ORGANISM(S): Homo sapiens (Human) 
2018-04-09 | PXD007995 | Pride
Human Ecm Lung Silac 
ProteomicsAlveolar epithelial cells are competent producers of interstitial extracellular matrix with disease relevant plasticity in a human in vitro 3D model
The structure of alveoli is critical for proper lung function, the extracellular matrix (ECM) that forms these delicate structures need to be maintained throughout life, when this fails, patients suffer from conditions such as emphysema or lung fibrosis. The alveolar walls are lined by alveolar epit...
ORGANISM(S): Homo sapiens (Human) 
2023-06-29 | PXD034531 | Pride
Human Ecm Ipf Copd Lung Remodeling Alveolar epithelium 
ProteomicsHuman plasma proteome changes during inhaled allergen challenge
Inhaled allergen challenge of subjects with allergic asthma allows the study of mechanisms involved in allergen-induced airway inflammation. The objective of this study was to identify changes in the plasma proteome associated with a late phase response (LPR) causing airway obstruction occurring 4-8...
ORGANISM(S): Homo sapiens (Human) 
2022-04-14 | PXD027091 | Pride
Human Late phase response Allergy Asthma Plasma 
ProteomicsPatient-derived model combining organoids and matrix reveals cholangiocarcinoma promoting properties of the microenvironment
Cholangiocarcinoma (CCA) is a rare but aggressive type of primary liver cancer, with an overall 5-year survival rate of <10%. The extracellular matrix (ECM) plays a particularly important role in CCA tumor biology, manifested in the desmoplastic tumor environment. This study aim is to design an in v...
ORGANISM(S): Homo sapiens (Human) 
2023-03-04 | PXD028408 | Pride
Human Organoids Tissue culture Liver Cholangiocarcionoma Extracellular matrix 
ProteomicsCholangiocyte organoid culture in hydrogels from decellularized liver tissue
Culture of human cholangiocyte organoids in hydrogels derived from healthy liver extracellular matrix (LECM) extracts prepared from decellularized human livers are evaluated in an effort to establish a platform for production of cholangiocyte organoids for clinical regenerative applications. Human ...
ORGANISM(S): Homo sapiens (Human) 
2022-04-13 | PXD028417 | Pride
Human Regeneration Hydrogel Liver Cholangiocyte Organoid 
ProteomicsProteome of human branching and non-branching cholangiocyte organoids
Current model systems for studying intrahepatic biliary disease fail to recapitulate the architecture of intrahepatic bile ducts. Organoids from intrahepatic cholangiocytes can with a new culture method grow with a branching pattern resembling the structure of intrahepatic bile ducts. This dataset c...
ORGANISM(S): Homo sapiens (Human) 
2022-05-09 | PXD028532 | Pride
Disease modelling Cholangiocyte organoids Cholangiocarcinoma Cholangiocytes Intrahepatic bile duct Branching morphogenesis Embryonic development 
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