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TranscriptomicsScf-GFP+ cells from the bone marrow and whole bone marrow microarray
The HSC niche factor SCF is required for HSC maintenance. Using an Scf-GFP knockin mouse, we have identified a perivascular cell type in the bone marrow expressing high level of Scf. To characterize the novel Scf-GFP+ cells from the bone marrow, we performed microarray analysis on these cells. Total...
ORGANISM(S): Mus musculus 
2012-02-01 | E-GEOD-33158 | biostudies-arrayexpress
ProteomicsSystemwide disassembly and assembly of SCF ubiquitin ligase complexes
Cells adapt to ever-changing environmental cues by remodeling their inventories of multiprotein complexes. The cellular repertoire of modular multiprotein SCF (SKP1-CUL1-Fbox protein) E3 ligase complexes - which mediate much protein degradation - requires CAND1 to distribute the limiting CUL1 subuni...
ORGANISM(S): Homo sapiens (Human) 
2023-04-14 | PXD038661 | Pride
Crl Ligase Cand1 Scf Formation Assembly Ubiquitin Complex E3 
ProteomicsSCF-Fbxo42 promotes synaptonemal complex assembly by downregulating PP2A-B56
Meiosis creates genetic diversity by recombination and segregation of chromosomes. The synaptonemal complex assembles during meiotic prophase I and assists faithful exchanges between homologous chromosomes, but how its assembly/disassembly is regulated remains to be understood. Here we report how ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2020-12-07 | PXD022755 | Pride
Drosophila 
ProteomicsC-terminal amides mark proteins for degradation via SCF/FBXO31
FBXO31 is a substrate adapter for the SCF-type ubiquitin ligase complex SCF/FBXO31 which ubiquitylates C-terminal amide-bearing proteins (CTAPs), thereby triggering their proteasomal degradation in human cells. Profiling of active cullin-RING ubiquitin E3 ligases was performed in naive or FBXO31 kno...
ORGANISM(S): Homo sapiens (Human) 
2024-11-07 | PXD055518 | Pride
Ligase Cullin Fbxo31 Ring Scf Ubiquitin E3 
ProteomicsC-terminal amides mark proteins for degradation via SCF/FBXO31 - Interaction Proteomics of FBXO31 in HEK293T cells
FBXO31 is a substrate adapter for the SCF-type ubiquitin ligase complex SCF/FBXO31 which ubiquitylates C-terminal amide-bearing proteins (CTAPs), thereby triggering their proteasomal degradation in human cells. Immunoprecipitation followed by MS (IP-MS) was performed on HA-tagged cDNA-expressed var...
ORGANISM(S): Homo sapiens (Human) 
2024-11-05 | PXD055535 | Pride
Ap-ms Fbxo31 Ip-ms Oxidative stress Ubiquitin ligase 
UnknownThe SCF Complex Is Essential to Maintain Genome and Chromosome Stability.
Not available
S-EPMC8395177 | biostudies-literature
UnknownSCF-Fbxo42 promotes synaptonemal complex assembly by downregulating PP2A-B56.
Not available
S-EPMC7780726 | biostudies-literature
UnknownThe Cdc34/SCF ubiquitination complex mediates Saccharomyces cerevisiae cell wall integrity.
Not available
S-EPMC1698636 | biostudies-literature
ProteomicsOxygen-dependent regulation of E3(SCF)ubiquitin ligases and a Skp1-associated JmjD6 homolog in Dictyostelium
The SCF (Skp1/cullin-1/F-box protein) class of E3 polyubiquitin ligases generates a signal for proteasomal degradation of thousands of proteins in animals. The evolutionary diversification of the F-box protein (FBP) family of substrate receptor subunits has challenged elucidation of these complexes ...
ORGANISM(S): Dictyostelium discoideum (Slime mold) 
2022-07-22 | PXD033864 | Pride
Lc-msms Glycosylation Dictyostelium Skp1 Scf Immunoprecipitation E3 
UnknownCritical Role of RPS4X in Modulating SCF Complex Formation and Cell Survival.
Not available
S-EPMC12561996 | biostudies-literature
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