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ProteomicsThe prion protein contributes to epithelial-to-mesenchymal transition in the mouse NMuMG epithelial cell model
The physiological function of the prion protein (PrP) has remained elusive despite its widely recognized role in neurodegenerative diseases and sustained efforts to understand its molecular biology. On the basis of its evolutionary relationship to ZIP zinc transporters, protein-protein interactions ...
ORGANISM(S): Mus musculus (Mouse) 
2015-07-10 | PXD001875 | Pride
Epithelial-to-mesenchymal transition Orbitrap fusion Tmt Prion protein 
ProteomicsGlobal quantitative proteomes of PrP-deficient mouse models
A popular method for studying the function of a given protein is to generate and characterize a suitable model deficient for its expression. Most researchers select mouse models for this purpose and investigate proteins of interest in the tissue they are most associated with. For the prion protein (...
ORGANISM(S): Mus musculus (Mouse) 
2016-06-01 | PXD003398 | Pride
Mass spectrometry Mouse Global proteome Prion protein 
ProteomicsCRISPR-Cas9-based knockout of the prion protein and its effect on the proteome
The molecular function of the cellular prion protein (PrPC) and the mechanism by which it may contribute to neurotoxicity in prion diseases and Alzheimer’s disease (AD) are only partially understood. Mouse neuroblastoma Neuro2a cells and, more recently, C2C12 myocytes and myotubes have emerged as po...
ORGANISM(S): Mus musculus (Mouse) 
2014-11-19 | PXD001301 | Pride
Crispr-cas9 Knockout Prion Kockdown 
ProteomicsTau interactome - The human tau interactome: binding to the ribonucleoproteome, and impaired binding of the P301L mutant to chaperones and the proteasome
The tau protein is central to the etiology of several neurodegenerative diseases, including Alzheimer’s disease, a subset of frontotemporal dementias, progressive supranuclear palsy and dementia following traumatic brain injury, yet the proteins it interacts with have not been studied using a system...
ORGANISM(S): Homo sapiens (Human) 
2015-08-17 | PXD002058 | Pride
Alzheimer Mass spectrometry Human Frontotemporal dementia Tau Interactome 
ProteomicsThe brain interactome of a permissive prion replication substrate
Bank voles are susceptible to prion strains from many different species, yet the molecular mechanisms underlying the ability of bank vole prion protein (BVPrP) to function as a universal prion acceptor remain unclear. Potential differences in molecular environments and protein interaction networks o...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-06 | PXD059662 | Pride
Mass spectrometry Bank voles Prion Knock-in mice Protein-protein interactions 
ProteomicsSomatostatin-interacting human brain proteins
Somatostatin (SST) is a cyclic peptide that is understood to inhibit the release of hormones and neurotransmitters from a variety of cells by binding to one of five canonical G protein-coupled SST receptors (SSTR1 to SSTR5). Recently, SST was observed to also interact with the amyloid beta (Aβ) pept...
ORGANISM(S): Homo sapiens (Human) 
2019-04-04 | PXD010885 | Pride
Somatostatin Brain Alzheimer disease Human Orbitrap Amyloid beta Neuroendocrine Biotinylation Endocrine Interactome 
ProteomicsMEF2A Interactome in rat cardiomyocyte
Myocyte enhancer factor 2 A was immunoprecipitated from primary cardiomyocytes then sequenced along with its binding partners by LC-MS2 with data dependent acquisition and simultaneous isobaric label based quantification.
ORGANISM(S): Rattus norvegicus (Rat) 
2023-02-21 | PXD038574 | Pride
Heart Mef2a Rat Cardiomyocyte Interactome 
ProteomicsThe human amyloid beta peptide interactome
The amyloid beta (Aβ) peptide represents a 37 to 49 amino acids endoproteolytic fragment of the amyloid precursor protein. The cellular biology that governs the formation and clearance of Aβ has been understood to play a critical role in Alzheimer’s disease (AD). The primary objective of this study...
ORGANISM(S): Homo sapiens (Human) 
2017-07-05 | PXD004867 | Pride
Brain Affinity purification Alzheimer’s disease Human Frontal lobe Orbitrap Amyloid beta 
ProteomicsInteractomes of neural cell adhesion molecule 1 and the metal ion transporter ZIP6 in mouse NMuMG epithelial cells with transforming growth factor beta 1-induced fibroblastoid morphology
The prion protein (PrP) evolved from the subbranch of ZIP metal ion transporters comprising ZIPs 5, 6 and 10, raising the prospect that the study of these ZIPs may reveal insights relevant for understanding PrP function. PrP and ZIP6 are required for the execution of a cellular program known as epi...
ORGANISM(S): Mus musculus (Mouse) 
2017-02-13 | PXD004685 | Pride
Zip zinc transporter Prion protein Cell culture Crispr-cas9 knockout Orbitrap Mouse Immunoprecipitation Nmumg Epithelial-to-mesenchymal transition 
ProteomicsComparative interactome analyses of wild-type and P301L MAPT in two human neuronal cell lines
Protein interactions of the tau protein are of interest in efforts to decipher the mechanisms of cell death in Alzheimer Disease (AD), a subset of frontotemporal dementias (FTD) and other tauopathies. We recently reported on extensive interactions of tau with the ribonucleoproteome and chaperones. A...
ORGANISM(S): Homo sapiens (Human) 
2019-11-13 | PXD010040 | Pride
Tauopathy Neuron Alzheimer disease Human Frontotemporal dementia Inducible expression Orbitrap Tau Interactome Mapt 
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