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ProteomicsCXMS BS3 Ras/BRAF/MEK/1433 complex
RAF-family kinases are activated by recruitment to the plasma membrane by GTP-bound RAS, where they initiate signaling through the MAP kinase cascade. Here we crosslinked (BS3), digested (trypsin), and analyzed via LC-MS/MS KRAS (human, residues 1-169) bound to intact BRAF (human) in an autoinhibit...
ORGANISM(S): Spodoptera frugiperda Homo sapiens (Human) 
2023-10-24 | PXD042584 | Pride
Cxms Human Braf Mek1 14-3-3 Sf9 Kras 
ProteomicsBiotinylated MMH2 pulldown LCMS
Here, we present structural and mechanistic studies that define a trans-labeling covalent molecular glue mechanism. We found that a novel series of BRD4 molecular glue degraders act by recruiting the CUL4-DCAF16 ligase to the second bromodomain of BRD4. To gain a deeper understanding into the potent...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051457 | Pride
Human Lc-msms Molecular glue 
ProteomicsA chaperone-assisted mechanism of outer mitochondrial membrane TOM70 insertion protective against diet-induced obesity
Outer mitochondrial membrane (OMM) proteins communicate with the cytosol and other organelles including the endoplasmic reticulum (ER). This communication is important in thermogenic adipocytes to increase energy expenditure that controls body temperature and weight. However, the regulatory mechanis...
ORGANISM(S): Homo sapiens (Human) 
2024-10-03 | PXD053607 | Pride
Xlms Tom70 Clms Crosslinking 
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