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ProteomicsEarly fallopian tube lesions and HGSC multiomics dataset
High-grade serous cancer (HGSC) of the ovary is the most common ovarian cancer subtype, typically diagnosed at late stages with a poor prognosis. Understanding early molecular events driving HGSC progression is crucial for developing effective detection strategies. We integrated spatial cell-type re...
ORGANISM(S): Homo sapiens (Human) 
2026-09-22 | PXD062349 | Pride
Fallopian tube cancer precursors Ovarian cancer Spatial multiomics Hgsc 
ProteomicsDeep Visual Proteomics defines single-cell identity and heterogeneity
Despite the availabilty of imaging-based and mass-spectrometry-based methods for spatial proteomics, a key challenge remains connecting images with single-cell-resolution protein abundance measurements. Here we introduce Deep Visual Proteomics (DVP), which combines artificial-intelligence-driven ima...
ORGANISM(S): Homo sapiens (Human) 
2022-04-27 | PXD023904 | Pride
Microscopy Digital pathology Proteomics Laser microdissection 
ProteomicsEarly fallopian tube lesions and HGSC spatial proteomics dataset
High-grade serous carcinoma (HGSC) is the most common ovarian cancer subtype, typically diagnosed at late stages with poor prognosis. Understanding early molecular events driving HGSC progression is crucial for early-stage cancer detection and development of effective treatment stategies. We perform...
ORGANISM(S): Homo sapiens (Human) 
2026-09-29 | PXD084823 | Pride
Fallopian tube cancer precursors Ovarian cancer Spatial proteomics Hgsc Stic (serous tubal intraepithelial carcinoma) 
ProteomicsA standardized and reproducible workflow for membrane glass slides in routine histology and spatial proteomics
Defining the molecular phenotype of single cells in-situ is essential for understanding tissue heterogeneity in health and disease. Powerful imaging technologies have recently been joined by spatial omics technologies, promising unparalleled insights into the molecular landscape of biological sample...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD040281 | Pride
Antigen retrieval Spatial proteomics Deep visual proteomics Glycerol Membrane slides Histology Proteomics Heat-induced epitope retrieval Laser microdissection 
ProteomicsRobust dimethyl-based multiplex-DIA doubles single-cell proteome depth via a reference channel
Single-cell proteomics aims to characterize biological function and heterogeneity at the level of proteins in an unbiased manner. It is currently limited in proteomic depth, throughput, and robustness, which we address here by a streamlined multiplexed workflow using data-independent acquisition (mD...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-12-22 | MSV000090956 | MassIVE
ProteomicsA new parallel high-pressure packing system enables rapid multiplexed production of capillary columns
Reversed-phase high performance liquid chromatography is the most commonly applied separation technique in mass spectrometry-based proteomics. Particle-packed capillary columns are predominantly used for nano-flow systems. Despite being the broadly applied standard for many years capillary columns a...
ORGANISM(S): Homo sapiens (Human) 
2021-04-28 | PXD024296 | Pride
Lc-ms Chromatography Capillary columns 
ProteomicsA streamlined mass spectrometry-based proteomics workflow for large scale FFPE tissue analysis
Formalin fixation and paraffin-embedding (FFPE) is the most common method to preserve human tissue for clinical diagnosis and FFPE archives represent an invaluable resource for biomedical research. Proteins in FFPE material are stable over decades but their efficient extraction and streamlined analy...
ORGANISM(S): Homo sapiens (Human) 
2020-04-02 | PXD017269 | Pride
Biobank Ffpe Cancer Proteomics Tissue Mass spectrometry Protocol 
Proteomicsproteomics of pediatric adrenocortical tumors
Pediatric adrenocortical tumors (pACT) are biologically heterogeneous and incompletely classified by histopathology. To elucidate proteome-level tumor organization, we performed mass spectrometry–based proteomic profiling of 83 pACT and 43 normal adrenal samples. Unsupervised clustering identified f...
ORGANISM(S): Homo sapiens (Human) 
2026-10-26 | PXD080313 | Pride
Adrenocortical tumors Adrenocortical carcinoma Adrenocortical adenoma Pediatric cancer 
ProteomicsAn evolutionary conserved, immobility associated antithrombotic mechanism
Venous thromboembolism (VTE) comprising deep venous thrombosis and pulmonary embolism is a main cause of morbidity and mortality that causes tremendous health care costs. Short term immobility related conditions arising from hospitalization, acute trauma and forced bed rest are major risk factors fo...
ORGANISM(S): Homo sapiens (Human) 
2023-04-14 | PXD031521 | Pride
Vte Platelets 
ProteomicsAn evolutionary conserved, immobility associated antithrombotic mechanism
Venous thromboembolism (VTE) comprising deep venous thrombosis and pulmonary embolism is a main cause of morbidity and mortality that causes tremendous health care costs. Short term immobility related conditions arising from hospitalization, acute trauma and forced bed rest are major risk factors fo...
ORGANISM(S): Homo sapiens (Human) 
2023-04-14 | PXD039087 | Pride
Vte Platelets 
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